Different findings of morphological changes and functional decline in the vestibule and the semicircular canal in ipsilateral delayed endolymphatic hydrops
Different findings of morphological changes and functional decline in the vestibule and the semicircular canal in ipsilateral delayed endolymphatic hydrops
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同侧迟发性内淋巴积水前庭和半规管形态变化和功能下降的不同表现
DOI：
10.1016/j.clinph.2020.03.032
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发表时间：
2020-04
影响因子：
4.7
通讯作者：
Fang-Lu Chi
中科院分区：
文献类型：
--
作者：
Jing Yu;Yu-Juan Zhou;Xin-Da Xu;Liang Tian;Dong-Dong Ren;Chen-Ru Ding;Jing Wang;Fang-Lu Chi
目的通过分析迟发性内淋巴水肿（DEH）患者形态学和功能变化的相关性，阐明其病理生理过程。方法回顾性研究29例DEH患者。所有患者均通过热量测试、颈椎和眼前庭诱发肌源性电位以及内耳钆增强磁共振成像（MRI）进行评估。结果根据MRI，积水定位分为前庭积水（囊和耳室）（14%）、前庭和耳蜗积水（72%）、前庭、耳蜗和外侧半圆形管积水（14%）。功能减退时，可明显观察到前庭积水；然而，当MRI检测到前庭积水时，囊泡和胞室并不总是存在功能障碍。在LSCC中，功能测试的下降并不一定伴随着形态异常。然而，当MRI观察到LSCC水肿时，可以明确地发现功能障碍。结论MRI显示，血滴主要见于前庭。在前庭，异常通常是形态上的而不是功能上的，而在LSCC中，功能恶化比形态改变更常被发现。意义我们的研究结果为DEH患者的功能和形态学特征提供了新的视角。
ObjectiveTo elucidate the pathophysiological process by analyzing the correlation between morphological and functional changes in patients with delayed endolymphatic hydrops (DEH).MethodsTwenty-nine patients diagnosed with DEH were enrolled in this retrospective study. All patients were assessed using the caloric test, cervical and ocular vestibular evoked myogenic potentials, and gadolinium-enhanced magnetic resonance imaging (MRI) of the inner ear.ResultsAccording to the MRI, the hydrops localization was categorized as hydrops in the vestibule (saccule and utricle) (14%), hydrops in the vestibule and cochlea (72%), and hydrops in the vestibule, cochlea, and lateral semicircular canal (LSCC) (14%). Vestibular hydrops could definitely be observed as function declined; however, a dysfunction of both the saccule and utricle was not always present when vestibular hydrops was detected with MRI. In the LSCC, a decline in functional tests was not necessarily accompanied by morphological abnormalities. However, dysfunction could definitely be detected when LSCC hydrops was observed with MRI.ConclusionsHydrops can be found mainly in the vestibule as shown by MRI. In the vestibule, abnormalities are commonly morphologic rather than functional, whereas in the LSCC a functional deterioration can be detected more frequently than morphological changes.SignificanceOur findings can provide a new perspective on the functional and morphological characteristics of patients with DEH.
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DOI：
10.1159/000274693
发表时间：
1965
期刊：
--
影响因子：
--
作者：
R. Kimura;H. Schuknecht
通讯作者：
R. Kimura;H. Schuknecht
DOI：
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发表时间：
1973-10
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影响因子：
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作者：
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影响因子：
1.7
作者：
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Lee, Won Sang
DOI：
10.1017/s0022215113003289
发表时间：
2013-12
期刊：
The Journal of Laryngology & Otology
影响因子：
--
作者：
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通讯作者：
Xi Gu;Z. Fang;Ying Liu;Lin Sl;B. Han;Rong Zhang;Xi Chen
DOI：
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发表时间：
--
期刊：
--
影响因子：
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作者：
D. J. Pender
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D. J. Pender