Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium.
Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium.
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DOI：
10.1111/bjh.14199
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发表时间：
2016-10
影响因子：
6.5
通讯作者：
de Roos AJ
中科院分区：
文献类型：
--
作者：
Schinasi LH;Brown EE;Camp NJ;Wang SS;Hofmann JN;Chiu BC;Miligi L;Beane Freeman LE;de Sanjose S;Bernstein L;Monnereau A;Clavel J;Tricot GJ;Atanackovic D;Cocco P;Orsi L;Dosman JA;McLaughlin JR;Purdue MP;Cozen W;Spinelli JJ;de Roos AJ
多发性骨髓瘤（MM）的家族集群提示疾病的遗传性。然而，遗传模式和遗传与环境风险因素在MM病因学中的重要性仍不清楚。我们汇集了来自国际多发性骨髓瘤协会的11项病例对照研究的数据，以表征MM风险与有淋巴-造血癌史的一级亲属之间的关系。使用经研究、性别、年龄和教育水平调整的无条件logistic回归模型来估计MM风险与有非霍奇金淋巴瘤、霍奇金淋巴瘤、白血病或MM病史的一级亲属之间的关联。性别、非裔美国人种族/民族和年龄作为影响调节因素进行了探讨。共纳入2843例病例和11470例对照。MM风险升高与一级亲属患有任何淋巴-造血肿瘤相关(优势比（OR)= 1.29, 95%可信区间（CI）： 1.08-1.55）。与MM有一级亲属的相关性特别强（OR= 1.90, 95% CI: 1.26-2.87），尤其是男性（OR= 4.13, 95% CI: 2.17-7.85）和非裔美国人（OR= 5.52, 95% CI: 1.87-16.27）。这些结果支持了遗传在MM病因学中起作用的假设。未来的研究有必要描述遗传标记与环境暴露的相互作用。
Family clusters of multiple myeloma (MM) suggest disease heritability. Nevertheless, patterns of inheritance and the importance of genetic versus environmental risk factors in MM aetiology remain unclear. We pooled data from eleven case-control studies from the International Multiple Myeloma Consortium to characterize the association of MM risk with having a first-degree relative with a history of a lympho-haematapoietic cancer. Unconditional logistic regression models, adjusted for study, sex, age and education level, were used to estimate associations between MM risk and having a first-degree relative with a history of non-Hodgkin lymphoma, Hodgkin lymphoma, leukaemia or MM. Sex, African American race/ethnicity and age were explored as effect modifiers. A total of 2,843 cases and 11,470 controls were included. MM risk was elevated in association with having a first-degree relative with any lympho-haematapoietic cancer (Odds Ratio (OR)= 1.29, 95% Confidence Interval (CI): 1.08-1.55). The association was particularly strong for having a first-degree relative with MM (OR= 1.90, 95% CI: 1.26-2.87), especially among men (OR= 4.13, 95% CI: 2.17-7.85) and African Americans (OR= 5.52, 95% CI: 1.87-16.27). These results support the hypothesis that genetic inheritance plays a role in MM aetiology. Future studies are warranted to characterize interactions of genetic markers with environmental exposures.
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影响因子：
10.3
作者：
Chang, ET;Smedby, KE;Adami, HO
通讯作者：
Adami, HO
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2.3
作者：
ERIKSSON, M;HALLBERG, B
通讯作者：
HALLBERG, B
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8.4
作者：
Altieri, Andrea;Chen, Bowang;Hemminki, Kari
通讯作者：
Hemminki, Kari
影响因子：
6.4
作者：
Landgren, O;Linet, MS;Goldin, LR
通讯作者：
Goldin, LR
影响因子：
51.1
作者：
Grass, Sandra;Preuss, Klaus-Dieter;Pfreundschuh, Michael
通讯作者：
Pfreundschuh, Michael