Effects of Equol Supplement on Bone and Cardiovascular Parameters in Middle-Aged Japanese Women: A Prospective Observational Study.
Effects of Equol Supplement on Bone and Cardiovascular Parameters in Middle-Aged Japanese Women: A Prospective Observational Study.
复制标题
DOI：
10.1089/acm.2018.0050
复制
发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Ohta H
中科院分区：
文献类型：
--
作者：
Yoshikata R;Myint KZY;Ohta H
目的：研究中年日本女性服用雌马酚补充剂一年后，骨骼和心血管参数的变化以及耐受性。设计：这是一项前瞻性观察研究。受试者和设置：参与者是2013年至2015年在东京港区Hamasite医疗诊所接受门诊治疗的74名女性。干预措施：参与者接受口服含雌马酚的补充剂，10 mg/天。结果测量：主要结果测量是补充雌马酚1年后骨和心血管参数的百分比变化。次要指标包括影响参数变化的因素和与使用雌马酚一年相关的不良反应。结果：在补充雌马酚12个月后，观察到动脉硬度降低（1402.3 cm/s vs.1367.3 cm/s，p < 0.001）。在动脉硬化中度和高度风险的女性中观察到相应参数的显著降低（中位数[95%置信区间]：分别为−3.2% [−5.79至−0.74]; −12.65% [−18.52至−4.28]）;高脂血症−45.53% [−70.24至−5.58];骨吸收风险（−15.15% [−23.71至1.56];骨折风险−26.68% [−76.43至−5.99]。所有15名基线甲状旁腺激素水平高的女性都实现了从基线值下降50% [-54.11到-31.69]的中位数。多元线性回归分析的结果进一步证实了这些关联。在定期随访期间，未报告血液化学、巴氏涂片、乳房X线摄影和经阴道超声的不良事件或异常结果。结论：一年的雌马酚补充是可以忍受的，并引起某些骨和心血管参数的改善，特别是在高危人群中。需要进一步的对照研究来探索长期使用雌马酚对中年妇女的健康的影响。
Objective: To examine changes in the bone and cardiovascular parameters and tolerability in middle-aged Japanese women taking equol supplement for a year. Design: This was a prospective observational study. Subjects and Setting: Participants were 74 women receiving outpatient care at Hamasite Medical Clinic, Minato-ku, Tokyo, from 2013 to 2015. Interventions: Participants received per oral equol-containing supplement, 10 mg/day. Outcome measures: The primary outcome measures were percent changes in bone and cardiovascular parameters after 1 year supplementation with equol. The secondary measures included factors affecting the parameter changes and adverse effects associated with equol use for a year. Results: Reduction in arterial stiffness was observed after 12 months of equol supplement (1402.3 cm/s vs.1367.3 cm/s, p < 0.001). Significant reductions in respective parameters were observed in women with moderate and high risk for arteriosclerosis (median [95% confidence interval]: −3.2% [−5.79 to −0.74]; −12.65% [−18.52 to −4.28]; respectively); hypertriglyceridemia −45.53% [−70.24 to −5.58]; bone resorption risk (−15.15% [−23.71 to 1.56]; and bone fracture risk −26.68% [−76.43 to −5.99]. All 15 women with high baseline parathyroid hormone levels had achieved a median of 50% [−54.11 to −31.69] reduction from their baseline values. These associations were further confirmed in the results of multiple linear regression analysis. There were no reported adverse events or abnormal findings in the blood chemistry, Pap smear, mammography, and transvaginal ultrasound during periodic follow-ups. Conclusion: One year equol supplement was tolerable and induced improvement of certain bone and cardiovascular parameters, especially in higher risk groups. Further controlled studies are needed to explore long-term equol use for wellbeing of middle-aged women.
登录
查看更多内容
影响因子：
5.6
作者：
Franke, Adrian A.;Lai, Jennifer F.;Halm, Brunhild M.;Pagano, Ian;Kono, Naoka;Mack, Wendy J.;Hodis, Howard N.
通讯作者：
Hodis, Howard N.
影响因子：
3.9
作者：
Liu, Y;Hu, M
通讯作者：
Hu, M
影响因子：
3.9
作者：
Meyer, BJ;Larkin, TA;Howe, PRC
通讯作者：
Howe, PRC
影响因子：
3.5
作者：
Day, AJ;DuPont, MS;Williamson, G
通讯作者：
Williamson, G
影响因子：
2.8
作者：
Decroos, K;Vanhemmens, S;Verstraete, W
通讯作者：
Verstraete, W