Equol production changes over time in postmenopausal women.
Equol production changes over time in postmenopausal women.
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DOI：
10.1016/j.jnutbio.2011.03.002
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发表时间：
2012-06
影响因子：
5.6
通讯作者：
Hodis, Howard N.
中科院分区：
文献类型：
--
作者：
Franke, Adrian A.;Lai, Jennifer F.;Halm, Brunhild M.;Pagano, Ian;Kono, Naoka;Mack, Wendy J.;Hodis, Howard N.
雌马酚（EQ）是由30%-60%的人群中的大豆异黄酮（DE）肠道细菌产生的，据信大豆摄入量有益于人体健康。缺乏强有力的EQ状态定义，并且不确定EQ是否在个体内持续形成并在口服抗生素治疗后停止。在一项随机、双盲、安慰剂对照的大豆干预试验中，对350名绝经后妇女在基线和2.5年内每6个月一次的过夜尿、点尿和血浆中的DE和EQ进行了液相色谱/串联质谱分析。评估了雌马酚生产变化和状态（保持为EQ生产者或非生产者或向EQ生产者或非生产者转变）。最依赖于隔夜尿液，以EQ/DE≥0.018和DE阈值≥2 nmol/mg肌酐作为临界值，确定雌马酚状态：在研究期间，大豆组和安慰剂组有大约30%的EQ生产者保持一致，但分别有14%和35%的EQ状态发生改变（平均1.4-1.7倍），而分别有27%和17%的患者接受了抗生素治疗（反向相关P<0.01）。当过夜尿液仅限于最接近抗生素治疗前后的采集时，未观察到EQ产生或状态变化的显著趋势。同样，抗生素类型或类别、持续时间、剂量或抗生素治疗与过夜尿液收集之间的时间对EQ产生无一致影响。雌马酚的产生可以在2.5年内发生显着的变化，抗生素治疗对其影响不一致。必须考虑抗生素治疗以外的因素作为EQ产生变化的原因。
Equol (EQ) is produced by intestinal bacteria from the soy isoflavone daidzein (DE) in 30%–60% of the population and is believed to provide benefits from soy intake. A robust EQ status definition is lacking, and it is uncertain whether EQ is formed consistently within an individual and ceases upon oral antibiotic treatment. In a randomized, double-blind, placebo-controlled soy intervention trial with 350 postmenopausal women, DE and EQ were analyzed by liquid chromatography/tandem mass spectrometry at baseline and every 6 months over 2.5 years in overnight urine, spot urine and plasma. Equol production changes and status (remaining an EQ producer or nonproducer or changing towards an EQ producer or nonproducer) were assessed. Equol status was determined most dependably by overnight urine applying as cutoff a ratio of EQ/DE≥0.018 with a DE threshold ≥2 nmol/mg creatinine: the soy and placebo groups had approximately 30% consistent EQ producers during the study, but 14% and 35%, respectively, changed EQ status (mean 1.4–1.7 times), while 27% and 17%, respectively, had antibiotic treatment (P<.01 for inverse association). No significant trend in change of EQ production or status was observed when overnight urine was limited to collections closest to before and after antibiotic treatment. Similarly, antibiotic type or class, duration, dose or time between antibiotic treatment and overnight urine collection showed no consistent influence on EQ production. Equol production can markedly change intraindividually over 2.5 years, and antibiotic treatment impacts it inconsistently. Factors other than antibiotic treatment must be considered as causes for EQ production changes.
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影响因子：
2.9
作者：
Franke, AA;Custer, LJ;Hundahl, SA
通讯作者：
Hundahl, SA
影响因子：
4.2
作者：
Lampe, JW;Skor, HE;Chen, C
通讯作者：
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影响因子：
7.1
作者：
Lampe, Johanna W.
通讯作者：
Lampe, Johanna W.
影响因子：
4.2
作者：
Lampe, Johanna W.
通讯作者：
Lampe, Johanna W.
DOI：
10.1158/1055-9965.epi-10-0116
发表时间：
2010-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Franke AA;Hebshi SM;Pagano I;Kono N;Mack WJ;Hodis HN
通讯作者：
Hodis HN