Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics.
Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics.
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DOI：
10.1016/j.joca.2014.05.016
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发表时间：
2014-10
影响因子：
7
通讯作者：
Neu, C. P.
中科院分区：
文献类型：
--
作者：
Neu, C. P.
功能成像广泛地指使用医学图像模态的器官或组织生理学的可视化。在身体的承重组织中，包括衬在关节骨端的关节软骨，骨关节炎（OA）中发生应变、应力和材料性质的变化，从而提供了通过疾病进展来探测组织功能的机会。在这里，软骨和相关关节组织的生物力学措施进行了讨论，作为关键的影像学生物标志物在评估骨关节炎。重点将放在a）放射摄影、超声和磁共振成像评估OA早期组织病理机制的潜力，B）运动学、结构、形态学和生物力学指标作为功能性成像生物标志物的相对效用，以及c）通过多种成像生物标志物与独特对比的组合提高诊断特异性，包括弹性成像和组织生物化学的定量评估。与其他方式相比，磁共振成像在组织水平上提供了广泛的功能测量，传统和新兴技术可用于评估临床前至进展OA的范围。
Functional imaging refers broadly to the visualization of organ or tissue physiology using medical image modalities. In load-bearing tissues of the body, including articular cartilage lining the bony ends of joints, changes in strain, stress, and material properties occur in osteoarthritis (OA), providing an opportunity to probe tissue function through the progression of the disease. Here, biomechanical measures in cartilage and related joint tissues are discussed as key imaging biomarkers in the evaluation of OA. Emphasis will be placed on the a) potential of radiography, ultrasound, and magnetic resonance imaging to assess early tissue pathomechanics in OA, b) relative utility of kinematic, structural, morphological, and biomechanical measures as functional imaging biomarkers, and c) improved diagnostic specificity through the combination of multiple imaging biomarkers with unique contrasts, including elastography and quantitative assessments of tissue biochemistry. In comparison to other modalities, magnetic resonance imaging provides an extensive range of functional measures at the tissue level, with conventional and emerging techniques available to potentially to assess the spectrum of preclinical to advance OA.
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影响因子：
7
作者：
Chan, S. M. T.;Neu, C. P.;Reddi, A. H.
通讯作者：
Reddi, A. H.
影响因子：
2.4
作者：
Butz, Kent D.;Chan, Deva D.;Neu, Corey P.
通讯作者：
Neu, Corey P.
影响因子：
2.4
作者：
Borotikar BS;Sipprell WH 3rd;Wible EE;Sheehan FT
通讯作者：
Sheehan FT
影响因子：
19.7
作者：
Bae, Won C.;Dwek, Jerry R.;Chung, Christine B.
通讯作者：
Chung, Christine B.
影响因子：
4
作者：
Burnett, W. D.;Kontulainen, S. A.;Johnston, J. D.
通讯作者：
Johnston, J. D.