Cannabis Legalization and Acute Harm From High Potency Cannabis Products: A Narrative Review and Recommendations for Public Health.
Cannabis Legalization and Acute Harm From High Potency Cannabis Products: A Narrative Review and Recommendations for Public Health.
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DOI：
10.3389/fpsyt.2020.591979
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发表时间：
2020
影响因子：
4.7
通讯作者：
Le Foll B
中科院分区：
文献类型：
--
作者：
Matheson J;Le Foll B
非医用大麻的合法化和商业销售导致大麻产品的多样性和效力不断增加。美国一些最早合法化的州出现了与大麻使用相关的急性危害的增加，例如科罗拉多因大麻相关的急性心理困扰和严重呕吐（剧吐）而急诊室就诊的人数增加，以及一些与摄入高剂量大麻食品有关的高调死亡。过量吸食大麻与多种因素有关，包括销售四氢大麻酚含量高的大麻产品，以及消费者对大麻产品标签的混淆，这对新用户或没有经验的用户产生了不成比例的影响。根据我们对文献的回顾，我们提出了三种方法来尽量减少急性危害：早期限制大麻食用品和高效产品;明确和一致的标签，传达剂量/服务大小和健康风险;并实施强有力的数据收集框架，以监测按大麻产品类型分列的危害（例如剂量、效力、给药途径）和消费者特征（例如年龄、性别、性别、种族）。在现有法律的大麻法律管辖区内持续收集数据和监测危害，对于了解大麻合法化的影响和最大限度地提高公共卫生效益至关重要。
Legalization and commercial sale of non-medical cannabis has led to increasing diversity and potency of cannabis products. Some of the American states that were the first to legalize have seen rises in acute harms associated with cannabis use, e.g. Colorado has seen increases in emergency department visits for cannabis-related acute psychological distress and severe vomiting (hyperemesis), as well as a number of high-profile deaths related to ingestion of high doses of cannabis edibles. Over-ingestion of cannabis is related to multiple factors, including the sale of cannabis products with high levels of THC and consumers’ confusion regarding labelling of cannabis products, which disproportionately impact new or inexperienced users. Based on our review of the literature, we propose three approaches to minimizing acute harms: early restriction of cannabis edibles and high-potency products; clear and consistent labelling that communicates dose/serving size and health risks; and implementation of robust data collection frameworks to monitor harms, broken down by cannabis product type (e.g. dose, potency, route of administration) and consumer characteristics (e.g. age, sex, gender, ethnicity). Ongoing data collection and monitoring of harms in jurisdictions that have existing legal cannabis laws will be vital to understanding the impact of cannabis legalization and maximizing public health benefits.
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DOI：
10.1016/s2215-0366(19)30048-3
发表时间：
2019-05
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Di Forti M;Quattrone D;Freeman TP;Tripoli G;Gayer-Anderson C;Quigley H;Rodriguez V;Jongsma HE;Ferraro L;La Cascia C;La Barbera D;Tarricone I;Berardi D;Szöke A;Arango C;Tortelli A;Velthorst E;Bernardo M;Del-Ben CM;Menezes PR;Selten JP;Jones PB;Kirkbride JB;Rutten BP;de Haan L;Sham PC;van Os J;Lewis CM;Lynskey M;Morgan C;Murray RM;EU-GEI WP2 Group
通讯作者：
EU-GEI WP2 Group
影响因子：
4.2
作者：
Allen, Jane A.;Davis, Kevin C.;Farrelly, Matthew C.
通讯作者：
Farrelly, Matthew C.
影响因子：
2.3
作者：
Anthony, James C.;Warner, Lynn A.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
影响因子：
4.4
作者：
Borodovsky, Jacob T.;Budney, Alan J.
通讯作者：
Budney, Alan J.
DOI：
10.1007/s00406-019-00983-5
发表时间：
2019-02-01
影响因子：
4.7
作者：
Chandra, Suman;Radwan, Mohamed M.;ElSohly, Mahmoud A.
通讯作者：
ElSohly, Mahmoud A.