Internal Cholinergic Regulation of Learning and Recall in a Model of Olfactory Processing.
Internal Cholinergic Regulation of Learning and Recall in a Model of Olfactory Processing.
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DOI：
10.3389/fncel.2016.00256
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发表时间：
2016
影响因子：
5.3
通讯作者：
Linster C
中科院分区：
文献类型：
--
作者：
de Almeida L;Idiart M;Dean O;Devore S;Smith DM;Linster C
在嗅觉系统中，胆碱能调节与对比调节和嗅球感受野的变化以及嗅觉皮层中气味关联的学习有关。计算模型和行为研究表明，胆碱能调节可以改善感觉处理和学习，同时防止任务要求高时的主动干扰。然而，感官输入和/或学习如何调节传入调制尚未阐明。我们在这里使用嗅球、梨状皮层 (PC) 和布罗卡对角带水平肢 (HDB) 的计算模型来探索嗅觉学习如何在闭合反馈环中调节系统的胆碱能输入。在我们的模型中，气味的新颖性反映在皮质神经元响应该气味的放电率和稀疏性上，这些放电率可以通过修改系统的胆碱能输入来直接调节系统中的学习。在该模型中，胆碱能神经元会减少对熟悉气味的反应——降低PC的可塑性，但会增加对新气味的反应——增加PC的可塑性。清醒行为大鼠的 HDB 神经元的记录反映了模型的预测，表明当气味变得熟悉时，一部分神经元会减少放电。
In the olfactory system, cholinergic modulation has been associated with contrast modulation and changes in receptive fields in the olfactory bulb, as well the learning of odor associations in olfactory cortex. Computational modeling and behavioral studies suggest that cholinergic modulation could improve sensory processing and learning while preventing pro-active interference when task demands are high. However, how sensory inputs and/or learning regulate incoming modulation has not yet been elucidated. We here use a computational model of the olfactory bulb, piriform cortex (PC) and horizontal limb of the diagonal band of Broca (HDB) to explore how olfactory learning could regulate cholinergic inputs to the system in a closed feedback loop. In our model, the novelty of an odor is reflected in firing rates and sparseness of cortical neurons in response to that odor and these firing rates can directly regulate learning in the system by modifying cholinergic inputs to the system. In the model, cholinergic neurons reduce their firing in response to familiar odors—reducing plasticity in the PC, but increase their firing in response to novel odor—increasing PC plasticity. Recordings from HDB neurons in awake behaving rats reflect predictions from the model by showing that a subset of neurons decrease their firing as an odor becomes familiar.
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影响因子：
3.4
作者：
Crespo, C;Blasco-Ibáñez, JM;Martínez-Guijarro, FJ
通讯作者：
Martínez-Guijarro, FJ
影响因子：
3.3
作者：
BRASHEAR, HR;ZABORSZKY, L;HEIMER, L
通讯作者：
HEIMER, L
影响因子：
2.7
作者：
Hasselmo, ME;Cekic, M
通讯作者：
Cekic, M
延髓乙酰胆碱增强神经和感知气味辨别能力。
DOI：
10.1523/jneurosci.4036-08.2009
发表时间：
2009-01-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chaudhury D;Escanilla O;Linster C
通讯作者：
Linster C
DOI：
10.1038/npp.2010.104
发表时间：
2011-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
通讯作者：
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