Impact of alcohol drinking on total cancer risk: data from a large-scale population-based cohort study in Japan.
Impact of alcohol drinking on total cancer risk: data from a large-scale population-based cohort study in Japan.
复制标题
DOI：
10.1038/sj.bjc.6602277
复制
发表时间：
2005-01-17
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
我们对73281名年龄在40 - 59岁的受试者（35007名男性和38274名女性）进行了一项为期10年的随访期的酒精消费与总癌症发病率和死亡率的队列研究。在1990 - 2001年期间，总共有3403例新诊断的癌症和1208例癌症死亡。在男性中，偶尔饮酒者患癌症的风险最低，并且注意到与乙醇摄入量增加呈线性正相关（每周1 - 149 g的风险比为1.18，每周150 - 299 g的风险比为1.17，每周300 - 449 g的风险比为1.43，每周1.61，趋势P <0.001）。癌症发病率和死亡率的正相关性相似，但在目前吸烟者和酒精相关癌症中更为显著。相对而言，很少有女性经常饮酒。我们的研究结果表明，增加乙醇摄入量会线性增加患癌症的风险，在这项研究中，近13%的男性癌症是由于大量饮酒（每周300克乙醇），吸烟是主要原因。因此，同时减少吸烟对于减少酒精对癌症风险的影响至关重要。
We conducted a cohort study of alcohol consumption and total cancer incidence and mortality in 73 281 subjects (35 007 men and 38 274 women) aged 40–59 years old at baseline over a 10-year follow-up period. During 1990–2001, a total of 3403 cases of newly diagnosed cancer and 1208 cancer deaths were identified. In men, the lowest risk of developing cancer was observed among occasional drinkers, and a linear positive association with increased ethanol intake was noted (hazard ratio 1.18 for 1–149 g per week, 1.17 for 150–299 g per week, 1.43 for 300–449 g per week, 1.61 for ⩾450 g per week, P for trend <0.001). The positive relation was similar for cancer incidence and mortality, but was more striking among current smokers and alcohol-related cancers. Relatively few women were regular drinkers. Our results suggest that increased ethanol intake linearly elevates the risk of cancer, and that nearly 13% of cancers among males in this study were due to heavy drinking (⩾300 g per week of ethanol), to which smoking substantially contributed. The simultaneous reduction of smoking is therefore important for reducing the effect of alcohol on cancer risk.
登录
查看更多内容
DOI：
10.15288/jsa.2001.62.783
发表时间：
2001-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Theobald, H;Johansson, SE;Engfeldt, P
通讯作者：
Engfeldt, P
影响因子：
2.3
作者：
VANDEWIEL, JAG;FIJNEMAN, PHS;BOS, RP
通讯作者：
BOS, RP
影响因子：
158.5
作者：
FUCHS, CS;STAMPFER, MJ;WILLETT, WC
通讯作者：
WILLETT, WC
DOI：
10.1016/s0735-1097(99)00531-8
发表时间：
2000-01-01
影响因子：
24
作者：
Gaziano, JM;Gaziano, TA;Buring, JE
通讯作者：
Buring, JE
影响因子：
--
作者：
Camargo, CA;Hennekens, CH;Stampfer, MJ
通讯作者：
Stampfer, MJ