Quantification metrics for telangiectasia using optical coherence tomography.
Quantification metrics for telangiectasia using optical coherence tomography.
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DOI：
10.1038/s41598-022-05272-1
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发表时间：
2022-02-02
影响因子：
4.6
通讯作者：
Brain Vascular Malformation Consortium HHT Investigator Group
中科院分区：
文献类型：
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作者：
Cardinell JL;Ramjist JM;Chen C;Shi W;Nguyen NQ;Yeretsian T;Choi M;Chen D;Clark DS;Curtis A;Kim H;Faughnan ME;Yang VXD;Brain Vascular Malformation Consortium HHT Investigator Group
遗传性出血性毛细血管扩张症（HHT）是一种常染色体显性遗传病，可导致全身血管畸形。最普遍和最容易发生的这些病变遍及皮肤和粘膜，经常破裂引起出血和贫血。最近潜在的高温高压治疗方法的增加产生了对定量指标的需求，这些指标可以客观地衡量新的和正在开发的治疗方法的疗效。我们采用光学相干断层扫描（OCT）——一种新型的高分辨率、非侵入性成像方式，对皮肤HHT病变随时间或整个治疗过程的行为进行成像和定量表征。本研究旨在检测皮肤HHT病变的详细形态学变化，以了解疾病的潜在动态过程。我们提出了为HHT量身定制的精细指标，该指标来自一项试点研究，该研究使用了3名HHT患者和6个病变，在多个成像日期的过程中，总共有26个病变图像。这些病变的初步结果在本文中与代表性的OCT图像一起提出。本研究为分析和了解HHT病变提供了一种新的客观方法，该方法采用微创、可及、经济高效的成像方式，定量描述形态学和血流。
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes vascular malformations throughout the body. The most prevalent and accessible of these lesions are found throughout the skin and mucosa, and often rupture causing bleeding and anemia. A recent increase in potential HHT treatments have created a demand for quantitative metrics that can objectively measure the efficacy of new and developing treatments. We employ optical coherence tomography (OCT)—a high resolution, non-invasive imaging modality in a novel pipeline to image and quantitatively characterize dermal HHT lesion behavior over time or throughout the course of treatment. This study is aimed at detecting detailed morphological changes of dermal HHT lesions to understand the underlying dynamic processes of the disease. We present refined metrics tailored for HHT, developed from a pilot study using 3 HHT patients and 6 lesions over the course of multiple imaging dates, totalling to 26 lesion images. Preliminary results from these lesions are presented in this paper alongside representative OCT images. This study provides a new objective method to analyse and understand HHT lesions using a minimally invasive, accessible, cost-effective, and efficient imaging modality with quantitative metrics describing morphology and blood flow.
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影响因子：
7.6
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
通讯作者：
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