High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography.
High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography.
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DOI：
10.1002/lsm.22339
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发表时间：
2015-03
影响因子：
2.4
通讯作者：
Wang, Ruikang K.
中科院分区：
文献类型：
--
作者：
Baran, Utku;Li, Yuandong;Choi, Woo June;Kalkan, Goknur;Wang, Ruikang K.
痤疮是一种常见的皮肤病，通常会导致疤痕。痤疮炎症造成的胶原蛋白和其他组织损伤会导致永久性皮肤纹理和微血管变化。在这项研究中，我们展示了基于光学相干断层扫描的微血管造影在检测痤疮皮损发生和疤痕发展过程中人体内面部皮肤的高分辨率、三维结构和微血管特征方面的能力。本研究使用实时扫频源光学相干断层扫描系统来获取人体皮肤的体积图像。该系统的工作中心波长为 1310 nm，A 线速率为 100 kHz，并且具有扩展的成像范围（空气中约 12 mm）。该系统使用手持式成像探头对志愿者面部皮肤上的痤疮病变进行成像。我们利用光学微血管造影（OMAG）技术来评估微血管和组织结构的变化。由于 OMAG 的高灵敏度，我们能够对毛细血管水平的微脉管系统进行成像，并可视化痤疮病变周围的重塑血管。此外，由 OMAG 测量得出的血管密度变化可作为评估人类皮肤疾病的替代生物标志物。与组织学或显微镜等其他技术相比，我们的技术可以在体内对深度达 1.5 毫米的 3D 组织结构和微脉管系统进行成像，而无需外源造影剂。所提出的结果有望通过检测体内人体皮肤内的皮肤血流量和结构变化来促进旨在治疗痤疮皮损疤痕以及其他常见皮肤病的临床试验。
Acne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography based microangiography in detecting high-resolution, three-dimensional structural and microvascular features of in vivo human facial skin during acne lesion initiation and scar development. A real time swept source optical coherence tomography system is used in this study to acquire volumetric images of human skin. The system operates on a central wavelength of 1310 nm with an A-line rate of 100 kHz, and with an extended imaging range (~12 mm in air). The system uses a handheld imaging probe to image acne lesion on a facial skin of a volunteer. We utilize optical microangiography (OMAG) technique to evaluate the changes in microvasculature and tissue structure. Thanks to the high sensitivity of OMAG, we are able to image microvasculature up to capillary level and visualize the remodeled vessels around the acne lesion. Moreover, vascular density change derived from OMAG measurement is provided as an alternative biomarker for the assessment of human skin diseases. In contrast to other techniques like histology or microscopy, our technique made it possible to image 3D tissue structure and microvasculature up to 1.5 mm depth in vivo without the need of exogenous contrast agents. The presented results are promising to facilitate clinical trials aiming to treat acne lesion scarring, as well as other prevalent skin diseases, by detecting cutaneous blood flow and structural changes within human skin in vivo.
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影响因子：
3.8
作者：
An L;Qin J;Wang RK
通讯作者：
Wang RK
影响因子：
10.3
作者：
Greaves, N. S.;Benatar, B.;Bayat, A.
通讯作者：
Bayat, A.
影响因子：
2.4
作者：
Qin, Jia;Jiang, Jingying;An, Lin;Gareau, Daniel;Wang, Ruikang K.
通讯作者：
Wang, Ruikang K.
DOI：
10.3928/23258160-20140909-08
发表时间：
2014-09
期刊：
Ophthalmic surgery, lasers & imaging retina
影响因子：
--
作者：
Huang Y;Zhang Q;Thorell MR;An L;Durbin MK;Laron M;Sharma U;Gregori G;Rosenfeld PJ;Wang RK
通讯作者：
Wang RK
影响因子：
2.8
作者：
Baran, Utku;Shi, Lei;Wang, Ruikang K.
通讯作者：
Wang, Ruikang K.