Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.
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DOI：
10.1016/j.fertnstert.2008.08.067
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发表时间：
2008-10
影响因子：
6.7
通讯作者：
Guillette LJ Jr
中科院分区：
文献类型：
--
作者：
Crain DA;Janssen SJ;Edwards TM;Heindel J;Ho SM;Hunt P;Iguchi T;Juul A;McLachlan JA;Schwartz J;Skakkebaek N;Soto AM;Swan S;Walker C;Woodruff TK;Woodruff TJ;Giudice LC;Guillette LJ Jr
评价内分泌干扰物（EDCs）对女性生殖障碍的可能作用，强调生殖器官发育的可塑性和内分泌依赖的个体发育的复杂性。受孕率下降和女性生殖中断的发生率高，需要评估内分泌干扰物对女性生殖健康的影响。在一次研讨会上，对与内分泌干扰物对卵巢疾病（非整倍体、多囊卵巢综合征和周期改变）、子宫疾病（子宫内膜异位症、子宫肌瘤、胎儿生长受限和妊娠丢失）、乳腺疾病（乳腺癌、哺乳期缩短）和青春期时间的贡献相关的出版物进行了识别、审查和总结。回顾的数据表明，内分泌干扰物有助于许多人类女性生殖疾病，并强调早期生命阶段暴露的敏感性。许多研究差距被确定，限制了充分了解内分泌干扰物对女性生殖问题的贡献。此外，迫切需要减少这些生殖疾病的发病率，这可以通过对生命早期接触和成年生殖功能障碍进行相关研究，以及评估具体接触的工具和阻断其影响的方法来解决。这篇关于女性健康的EDC文献综述为改善女性健康提供了一个重要的平台。
To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health. Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop. The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women’s health can be improved.
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作者：
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通讯作者：
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