Soft fluorescent nanomaterials for biological and biomedical imaging.

Soft fluorescent nanomaterials for biological and biomedical imaging.
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DOI:
10.1039/c4cs00294f
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发表时间:
2015-07-21
影响因子:
46.2
通讯作者:
Chiu DT
Chiu DT
中科院分区:
化学1区
文献类型:
--
作者:
Peng HS;Chiu DT

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Soft fluorescent nanomaterials have attracted recent attention as imaging agents for biological applications, because they provide the advantages of good biocompatibility, high brightness, and easy biofunctionalization. Here, we provide a survey of recent developments in fluorescent soft nano-sized biological imaging agents. Various soft fluorescent nanoparticles (NPs) (including dye-doped polymer NPs, semiconducting polymer NPs, small-molecule organic NPs, nanogels, micelles, vesicles, and biomaterial-based NPs) are summarized from the perspectives of preparation method, structure, optical property, and surface functionalization. Based on both optical and functional properties of the nano-sized imaging agents, their applications are then reviewed in terms of in vitro imaging, in vivo imaging, and cellular-process imaging, by means of specific or nonspecific targeting.
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