Traditional Chinese Medicine is an Alternative Therapeutic Option for Treatment of Pseudomonas aeruginosa Infections.
Traditional Chinese Medicine is an Alternative Therapeutic Option for Treatment of Pseudomonas aeruginosa Infections.
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中医药是治疗铜绿假单胞菌感染的替代疗法。
DOI：
10.3389/fphar.2021.737252
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发表时间：
2021
影响因子：
5.6
通讯作者：
Zhu Q
中科院分区：
文献类型：
--
作者：
Pang Z;Zhu Q
铜绿假单胞菌是一种机会致病菌，在囊性纤维化患者和免疫功能低下的个体中引起危及生命的感染，并且它是与显著发病率和死亡率相关的医院感染的主要原因。由于对大多数传统抗生素的抗生素耐药性，铜绿假单胞菌感染的治疗具有挑战性。对于耐药感染的患者，迫切需要开发替代治疗方案。中医药防治感染性疾病已有数千年的临床历史，具有改善临床疗效、副作用小、抑制病原体、调节宿主免疫等优点。近年来的研究表明，中药天然产物在体外或动物模型中对铜绿假单胞菌耐药株有显著的抗菌作用，中药是治疗慢性铜绿假单胞菌感染的一种有效的补充和替代治疗方法。本文综述了近年来中医药抗铜绿假单胞菌感染的作用机制，并重点介绍了中医药对铜绿假单胞菌和宿主的分子靶点。
Pseudomonas aeruginosa is an opportunistic pathogen causing life-threatening infections in cystic fibrosis patients and immunocompromised individuals, and it is a leading cause of nosocomial infections associated with significant morbidity and mortality. Treatment of P. aeruginosa infections is challenging due to the antibiotic resistance to most of the conventional antibiotics. Development of alternative therapeutic options is urgently demanded for the patients who have antibiotic-resistant infections. Traditional Chinese medicine (TCM) has a clinical history of thousands of years for prevention and treatment of infectious diseases in China, taking advantages of improving clinical outcomes, producing less side effects, inhibiting pathogen, and modulating host immunity. Recent research has revealed a variety of natural products derived from TCM showing significant antimicrobial effects on antibiotic-resistant strains of P. aeruginosa alone or combined with antibiotics in vitro or in animal models, suggesting that TCM is a promising complementary and alternative therapeutic approach for treatment of chronic P. aeruginosa infections. This review summarizes the recent findings attempting to dissect the mechanisms of TCM combating P. aeruginosa infections and highlights the molecular targets of TCM on P. aeruginosa and host.
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DOI：
10.3390/molecules23010004
发表时间：
2017-12-21
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Chen H;Yu W;Chen G;Meng S;Xiang Z;He N
通讯作者：
He N
影响因子：
2.6
作者：
Ding, Junying;Gao, Xiang;Liu, Qingquan
通讯作者：
Liu, Qingquan
影响因子：
--
作者：
Chen CY;Li H;Yuan YN;Dai HQ;Yang B
通讯作者：
Yang B
影响因子：
3.8
作者：
Banerjee, Malabika;Moulick, Soumitra;Mukherjee, Samir Kumar
通讯作者：
Mukherjee, Samir Kumar
影响因子：
7.3
作者：
Gao, Hongwei;Cui, Yankun;Chen, Xiuping
通讯作者：
Chen, Xiuping