The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor.
The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor.
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DOI：
10.1038/s41398-020-01176-8
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发表时间：
2021-01-18
影响因子：
6.8
通讯作者：
John RM
中科院分区：
文献类型：
--
作者：
Dingsdale H;Nan X;Garay SM;Mueller A;Sumption LA;Chacón-Fernández P;Martinez-Garay I;Ghevaert C;Barde YA;John RM
脑源性神经营养因子（BDNF）在脑功能中起着至关重要的作用。许多研究报告了在各种神经系统疾病，包括情绪障碍，如抑郁症，在人类血清中BDNF水平的变化。然而，人们对怀孕期间血液中的BDNF水平知之甚少。我们询问了母亲（n = 251）和新生儿（n = 212）在怀孕期间的抑郁和/或焦虑是否与血清BDNF水平的改变有关。由于产前暴露于母亲的情绪障碍显着增加了神经系统疾病的风险，在以后的生活中，我们还研究了胎盘BDNF转移的可能性，通过开发一种新的小鼠模型。我们发现母亲抑郁症状与母亲或婴儿脐带血血清BDNF之间没有关联。然而，母亲的焦虑症状与显着升高的母亲血清BDNF仅在男孩的母亲（r = 0.281; P = 0.005; n = 99）。男婴血清BDNF水平显著低于女婴，但与母亲焦虑症状均无相关性。与这一观察结果一致，我们没有发现BDNF通过胎盘转移的证据。我们的结论是，胎盘保护发展中的胎儿从母亲的血清BDNF的变化，否则可能有不利后果的胎儿发育。
Brain-derived neurotrophic factor (BDNF) plays crucial roles in brain function. Numerous studies report alterations in BDNF levels in human serum in various neurological conditions, including mood disorders such as depression. However, little is known about BDNF levels in the blood during pregnancy. We asked whether maternal depression and/or anxiety during pregnancy were associated with altered serum BDNF levels in mothers (n = 251) and their new-born infants (n = 212). As prenatal exposure to maternal mood disorders significantly increases the risk of neurological conditions in later life, we also examined the possibility of placental BDNF transfer by developing a new mouse model. We found no association between maternal symptoms of depression and either maternal or infant cord blood serum BDNF. However, maternal symptoms of anxiety correlated with significantly raised maternal serum BDNF exclusively in mothers of boys (r = 0.281; P = 0.005; n = 99). Serum BDNF was significantly lower in male infants than female infants but neither correlated with maternal anxiety symptoms. Consistent with this observation, we found no evidence for BDNF transfer across the placenta. We conclude that the placenta protects the developing fetus from maternal changes in serum BDNF that could otherwise have adverse consequences for fetal development.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1017/s2040174417000617
发表时间：
2018-02-01
影响因子：
1.7
作者：
Ferrari, N.;Bae-Gartz, I.;Graf, C.
通讯作者：
Graf, C.