Prevalence of 2009 pandemic influenza A (H1N1) virus antibodies, Tampa Bay Florida--November-December, 2009.
Prevalence of 2009 pandemic influenza A (H1N1) virus antibodies, Tampa Bay Florida--November-December, 2009.
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DOI：
10.1371/journal.pone.0029301
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Fry AM
中科院分区：
文献类型：
--
作者：
Cox CM;Goodin K;Fisher E;Dawood FS;Hamilton JJ;Leparc GF;Gray M;Nelson L;Borse RH;Singleton JA;Reed C;Balish AL;Katz JM;Hopkins RS;Fry AM
2009年，一种新型流感病毒（2009年大流行性流感A（H1N1）病毒（pH 1 N1））在美国引起了重大疾病。包括佛罗里达在内的大多数州从9月到11月经历了一波大的秋季疾病浪潮，之后疾病活动大幅减少。我们确定了流感活动达到高峰后佛罗里达pH 1 N1病毒抗体的流行情况，并估计了大流行期间感染pH 1 N1病毒的人口比例。在2009年11月至12月期间，我们从佛罗里达坦帕湾的一家血库、一家儿科儿童医院和一家儿科门诊诊所收集了剩余血清。使用血凝抑制（HI）试验检测血清中的pH 1 N1病毒抗体。HI滴度≥40视为血清阳性。我们调整了血清阳性率结果，以说明先前建立的HI检测特异性和灵敏度，并采用一个简单的统计模型来估计由于pH 1 N1病毒感染和疫苗接种引起的血清阳性率的比例。在研究期间，佛罗里达坦帕湾的总体血清阳性率为25%，在调整HI检测灵敏度和特异性后增加至30%。我们估计，5.9%的人群有疫苗诱导的血清阳性，而25%的血清阳性继发于pH 1 N1病毒感染。pH 1 N1病毒感染的最高累积发病率为5-17岁的儿童（53%）和18-24岁的年轻人（47%），而≥50岁的成人pH 1 N1病毒感染的累积发病率最低（11-13%）。在大流行的秋季高峰之后，估计坦帕湾四分之一的人口感染了pH 1 N1病毒。与大流行期间观察到的流行病学趋势一致，学龄儿童和年轻人的疾病负担最高。
In 2009, a novel influenza virus (2009 pandemic influenza A (H1N1) virus (pH1N1)) caused significant disease in the United States. Most states, including Florida, experienced a large fall wave of disease from September through November, after which disease activity decreased substantially. We determined the prevalence of antibodies due to the pH1N1 virus in Florida after influenza activity had peaked and estimated the proportion of the population infected with pH1N1 virus during the pandemic. During November-December 2009, we collected leftover serum from a blood bank, a pediatric children's hospital and a pediatric outpatient clinic in Tampa Bay Florida. Serum was tested for pH1N1 virus antibodies using the hemagglutination-inhibition (HI) assay. HI titers ≥40 were considered seropositive. We adjusted seroprevalence results to account for previously established HI assay specificity and sensitivity and employed a simple statistical model to estimate the proportion of seropositivity due to pH1N1 virus infection and vaccination. During the study time period, the overall seroprevalence in Tampa Bay, Florida was 25%, increasing to 30% after adjusting for HI assay sensitivity and specificity. We estimated that 5.9% of the population had vaccine-induced seropositivity while 25% had seropositivity secondary to pH1N1 virus infection. The highest cumulative incidence of pH1N1 virus infection was among children aged 5–17 years (53%) and young adults aged 18–24 years (47%), while adults aged ≥50 years had the lowest cumulative incidence (11–13%) of pH1N1 virus infection. After the peak of the fall wave of the pandemic, an estimated one quarter of the Tampa Bay population had been infected with the pH1N1 virus. Consistent with epidemiologic trends observed during the pandemic, the highest burdens of disease were among school-aged children and young adults.
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影响因子：
12.7
作者：
Mak, Gannon C.;Choy, Perrin W. W.;Lim, Wilina
通讯作者：
Lim, Wilina
DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
120.7
作者：
Nolan, Terry;McVernon, Jodie;Greenberg, Michael
通讯作者：
Greenberg, Michael
影响因子：
11.8
作者：
Lim WY;Chen CH;Ma Y;Chen MI;Lee VJ;Cook AR;Tan LW;Flores Tabo N Jr;Barr I;Cui L;Lin RT;Leo YS;Chia KS
通讯作者：
Chia KS
影响因子：
3.7
作者：
Gilbert GL;Cretikos MA;Hueston L;Doukas G;O'Toole B;Dwyer DE
通讯作者：
Dwyer DE