Influenza A (H1N1) 2009 antibodies in residents of New South Wales, Australia, after the first pandemic wave in the 2009 southern hemisphere winter.
Influenza A (H1N1) 2009 antibodies in residents of New South Wales, Australia, after the first pandemic wave in the 2009 southern hemisphere winter.
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DOI：
10.1371/journal.pone.0012562
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发表时间：
2010-09-07
期刊：
影响因子：
3.7
通讯作者：
Dwyer DE
中科院分区：
文献类型：
--
作者：
Gilbert GL;Cretikos MA;Hueston L;Doukas G;O'Toole B;Dwyer DE
2009年5月，第一波甲型H1N1流感大流行（pH 1 N1）到达澳大利亚新南威尔士州（NSW），导致婴儿和年轻人到中年成人的流感相关住院率很高，但流感相关或全因死亡率没有增加。为了评估新南威尔士州居民的pH 1 N1感染率，在2009年冬季之前（2007-2008年; 474份标本）和之后（2009年8月至9月; 1247份标本）以及引入pH 1 N1单价疫苗之前，测量了机会性采集的标本中的pH 1 N1特异性血凝抑制（HI）抗体流行率。计算血清阳性率的年龄和地理加权的人群变化。测量针对四种最近的季节性甲型流感病毒的HI抗体以评估交叉反应。大流行前和大流行后pH 1 N1血清阳性率分别为12.8%和28.4%，估计总感染率为15.6%。1944年以后出生的人（1975年至1997年出生的人为26.9%）的pH 1 N1抗体患病率显著增加-总体为20.6%，但1944年或之前出生的人则没有增加。1925年以前出生的人的pH 1 N1血清阳性率显著高于其他任何年龄组，并对任何季节性流感病毒A。悉尼居民对pH 1 N1抗体的患病率比其他新南威尔士州居民有显着更大的变化（19.3%对9.6%）。根据第一波大流行前后pH 1 N1抗体流行率的增加，2009年16%的新南威尔士州居民感染了pH 1 N1;青少年和年轻人的感染率最高（27%）。既往暴露于抗原性相似的甲型H1N1流感（1918年）可能是大流行前交叉反应pH 1 N1抗体非常高的患病率（49%）以及85岁以上人群免于pH 1 N1感染的基础。除非季前疫苗接种率很高，否则在随后的冬天，年轻人中可能至少会出现中等比例的pH 1 N1感染，包括一些危及生命的病例。
The first wave of pandemic influenza A(H1N1)2009 (pH1N1) reached New South Wales (NSW), Australia in May 2009, and led to high rates of influenza-related hospital admission of infants and young to middle-aged adults, but no increase in influenza-related or all-cause mortality. To assess the population rate of pH1N1 infection in NSW residents, pH1N1-specific haemagglutination inhibition (HI) antibody prevalence was measured in specimens collected opportunistically before (2007–2008; 474 specimens) and after (August–September 2009; 1247 specimens) the 2009 winter, and before the introduction of the pH1N1 monovalent vaccine. Age- and geographically-weighted population changes in seroprevalence were calculated. HI antibodies against four recent seasonal influenza A viruses were measured to assess cross-reactions. Pre- and post-pandemic pH1N1 seroprevalences were 12.8%, and 28.4%, respectively, with an estimated overall infection rate of 15.6%. pH1N1 antibody prevalence increased significantly - 20.6% overall - in people born since 1944 (26.9% in those born between 1975 and 1997) but not in those born in or before 1944. People born before 1925 had a significantly higher pH1N1 seroprevalence than any other age-group, and against any seasonal influenza A virus. Sydney residents had a significantly greater change in prevalence of antibodies against pH1N1 than other NSW residents (19.3% vs 9.6%). Based on increases in the pH1N1 antibody prevalence before and after the first pandemic wave, 16% of NSW residents were infected by pH1N1 in 2009; the highest infection rates (27%) were among adolescents and young adults. Past exposure to the antigenically similar influenza A/H1N1(1918) is the likely basis for a very high prevalence (49%) of prepandemic cross-reacting pH1N1 antibody and sparing from pH1N1 infection among people over 85 years. Unless pre-season vaccine uptake is high, there are likely to be at least moderate rates including some life-threatening cases of pH1N1 infection among young people during subsequent winters.
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DOI：
10.1136/bmj.b3928
发表时间：
2009-10-06
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Garcia-Garcia L;Valdespino-Gómez JL;Lazcano-Ponce E;Jimenez-Corona A;Higuera-Iglesias A;Cruz-Hervert P;Cano-Arellano B;Garcia-Anaya A;Ferreira-Guerrero E;Baez-Saldaña R;Ferreyra-Reyes L;Ponce-de-León-Rosales S;Alpuche-Aranda C;Rodriguez-López MH;Perez-Padilla R;Hernandez-Avila M
通讯作者：
Hernandez-Avila M
影响因子：
168.9
作者：
Echevarria-Zuno, Santiago;Manuel Mejia-Arangure, Juan;Hugo Borja-Aburto, Victor
通讯作者：
Hugo Borja-Aburto, Victor
影响因子：
11.4
作者：
Kelly, Heath A.
通讯作者：
Kelly, Heath A.
影响因子：
158.5
作者：
Webb, Steven A. R.;Pettila, Ville;Yung, Michael
通讯作者：
Yung, Michael
2009 年 H1N1 甲型流感病毒的基因组特征和突变趋势分析
影响因子：
3.7
作者：
Pan C;Cheung B;Tan S;Li C;Li L;Liu S;Jiang S
通讯作者：
Jiang S