D1-like dopamine receptor density in nuclei involved in social behavior correlates with song in a context-dependent fashion in male European starlings.
D1-like dopamine receptor density in nuclei involved in social behavior correlates with song in a context-dependent fashion in male European starlings.
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DOI：
10.1016/j.neuroscience.2009.01.042
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发表时间：
2009-03-31
期刊：
影响因子：
3.3
通讯作者：
Riters, L. V.
中科院分区：
文献类型：
--
作者：
Heimovics, S. A.;Cornil, C. A.;Ball, G. F.;Riters, L. V.
关键词：
对鸣禽的研究表明，歌唱行为受到涉及发声行为和社会行为的大脑区域的调节。有趣的是，这些区域在鸣叫中的确切作用可能会随着社会、环境和繁殖背景的变化而变化。迄今为止，人们对这种依赖于环境的歌曲调节背后的神经递质知之甚少。多巴胺 (DA) 调节高度动机、目标导向的行为（包括性动机歌曲），新出现的数据表明 DA 参与了歌唱行为的上下文相关调节。进行这项研究的目的是开始检验 DA 受体的差异是否可能在一定程度上是歌曲产生中上下文依赖性差异的基础。我们使用放射自显影程序标记 D1 样和 D2 样 DA 受体，以检查雄性欧洲椋鸟 (Sturnus vulgaris) 在多种情况下 DA 受体密度与歌唱行为之间的关系。在繁殖环境中（当睾酮 (T) 高时），内侧视前核 (POM) 和中脑中央灰质 (GCt) 中的 D1 样受体密度与用于吸引雌性的鸣叫呈负相关。此外，在这种情况下，POM、GCt、终纹内侧床核 (BSTm) 和侧隔膜 (LS) 中的 D1 样受体密度与可能用于保护巢箱的鸣叫呈负相关。相反，在非繁殖环境中（当 T 较低时），POM 和 LS 中的 D1 样受体密度与用于维持社会群体的鸣叫呈正相关。任何背景下的歌曲与 D2 样受体密度之间均未发现任何关系。大脑区域的差异以及 D1 样受体结合与歌曲之间的方向关系表明多巴胺能系统在歌曲中发挥区域和上下文特定的作用。这些数据还表明，歌唱行为的个体差异可能部分是由与社会行为有关的大脑区域中 D1 样受体密度的个体差异来解释的。
Research in songbirds shows that singing behavior is regulated by both brain areas involved in vocal behavior as well as those involved in social behavior. Interestingly, the precise role of these regions in song can vary as a function of the social, environmental and breeding context. To date, little is known about the neurotransmitters underlying such context-dependent regulation of song. Dopamine (DA) modulates highly motivated, goal-directed behaviors (including sexually motivated song) and emerging data implicate DA in the context-dependent regulation of singing behavior. This study was performed to begin to examine whether differences in DA receptors may underlie, in part, context-dependent differences in song production. We used autoradiographic procedures to label D1-like and D2-like DA receptors to examine the relationship between DA receptor density and singing behavior in multiple contexts in male European starlings (Sturnus vulgaris). Within a breeding context (when testosterone (T) was high), D1-like receptor density in the medial preoptic nucleus (POM) and midbrain central gray (GCt) negatively correlated with song used to attract a female. Additionally in this context, D1-like receptor density in POM, GCt, medial bed nucleus of the stria terminalis (BSTm), and lateral septum (LS) negatively correlated with song likely used to defend a nestbox. In contrast, in a non-breeding context (when T was low), D1-like receptor density in POM and LS positively correlated with song used to maintain social flocks. No relationships were identified between song in any context and D2-like receptor densities. Differences in the brain regions and directional relationships between D1-like receptor binding and song suggest that dopaminergic systems play a region and context-specific role in song. These data also suggest that individual variation in singing behavior may, in part, be explained by individual differences in D1-like receptor density in brain regions implicated in social behavior.
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影响因子：
1.9
作者：
Burgdorf, J;Knutson, B;Ikemoto, S
通讯作者：
Ikemoto, S
DOI：
10.1086/physzool.60.2.30158643
发表时间：
1987-03-01
期刊：
PHYSIOLOGICAL ZOOLOGY
影响因子：
--
作者：
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通讯作者：
WINGFIELD, JC
影响因子：
1.3
作者：
EENS, M;PINXTEN, R;VERHEYEN, RF
通讯作者：
VERHEYEN, RF
影响因子：
1.7
作者：
Appeltants, D;Ball, GF;Balthazart, J
通讯作者：
Balthazart, J
影响因子：
2.5
作者：
BAILHACHE, T;BALTHAZART, J
通讯作者：
BALTHAZART, J