Immune Effects and Polychlorinated Biphenyls, Smoking and Alcohol
Immune Effects and Polychlorinated Biphenyls, Smoking and Alcohol
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免疫影响与多氯联苯、吸烟和饮酒
DOI：
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发表时间：
2012
影响因子：
3.5
通讯作者：
L. Soleo
中科院分区：
文献类型：
--
作者：
M. N. D'errico;G. De Tullio;M. Di Gioacchino;P. Lovreglio;A. Basso;I. Drago;R. Serra;P. Apostoli;A. Vacca;L. Soleo
多氯联苯（PCB）已被证明具有一定的免疫作用。在这里，我们分析了它们对以前未研究过的免疫参数的影响，如TCR α-β，TCR γ-δ和调节性T细胞（Treg），考虑到吸烟和酒精的特异性和累积干扰。研究对象包括26名男性工人在一家钢铁厂，受雇于电气维修部门，与以前接触的混合物的多氯联苯（暴露的主题），和30名男性工人没有职业接触多氯联苯（控制）。对所有受试者进行问卷调查，并采集外周静脉血，测定血清PCB（33种同系物）、总胆固醇和甘油三酯、白细胞、总淋巴细胞和T淋巴细胞亚群（TCR α-β、TCRγ-δ、CD 4+和Treg淋巴细胞）。多氯联苯，即使在一个非常低的浓度，显着高于暴露的受试者比对照组，并显着与年龄相关。与对照组相比，暴露受试者的单核细胞%和CD 4+显著降低。PCB血清浓度与TCR α-β呈显著正相关，与TCRγ-δ呈显著负相关。Treg淋巴细胞与吸烟呈正相关，而单核细胞百分比和CD 4+与饮酒呈负相关和正相关。我们的结果似乎显示了轻微暴露于PCB的一些影响，特别是降低TCRγ-δ的相对浓度。这种作用可以间接地促进由吸烟诱导的Treg的增加，其抗炎或促炎/纤维生成/血管生成作用，由产生的细胞因子，特别是TGF-β发挥，值得进一步澄清。
Polychlorinated biphenyls (PCB) have been shown to exert some immune effects. Here we analysed their effects also on immune parameters not previously studied such as TCR α-β, TCR γ-δ and regulatory T cells (Treg), taking into account the specific and cumulative interference of smoking and alcohol. The study subjects consisted of 26 male workers in a steelworks factory, employed in the electrical maintenance sector, with previous exposure to a mixture of PCB (exposed subjects), and 30 male workers with no occupational exposure to PCB (controls). All subjects were given a questionnaire and peripheral venous blood samples were taken to determine serum PCB (33 congeners), total cholesterol and triglycerides, leukocytes, total lymphocytes and the T lymphocyte subpopulations (TCR α-β, TCRγ-δ, CD4+ and Treg lymphocytes). PCB, even though at a very low concentration, were significantly higher in exposed subjects than controls, and were significantly correlated with age. Monocytes% and CD4+ were significantly reduced in the exposed subjects as compared to the controls. The serum concentration of PCB positively correlated with TCR α-β, and negatively with TCRγ-δ. Treg lymphocytes showed a positive dependence on tobacco smoking, while the monocytes% and CD4+ showed a negative and positive dependence, respectively, on alcohol intake. Our results seem to show some effects of slight exposure to PCB in particular reducing the relative concentration of TCRγ-δ. This effect can favour indirectly the increase in Treg induced by smoking, the anti-inflammatory or proinflammatory/fibrogenetic/angiogenetic effect of which, exerted by produced cytokines, particularly TGF-β, deserves further clarification.
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影响因子：
32.4
作者：
Petermann F;Rothhammer V;Claussen MC;Haas JD;Blanco LR;Heink S;Prinz I;Hemmer B;Kuchroo VK;Oukka M;Korn T
通讯作者：
Korn T
DOI：
10.1111/j.1530-0277.2008.00842.x
发表时间：
2009-02
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Szabo G;Mandrekar P
通讯作者：
Mandrekar P
影响因子：
4
作者：
T. Makinde;R. Murphy;D. Agrawal
通讯作者：
T. Makinde;R. Murphy;D. Agrawal
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
P. Molina;K. Happel;Ping Zhang;J. Kolls;S. Nelson;E. Patricia;Molina
通讯作者：
P. Molina;K. Happel;Ping Zhang;J. Kolls;S. Nelson;E. Patricia;Molina