Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species.
Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species.
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DOI：
10.1038/emi.2014.33
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发表时间：
2014-05
影响因子：
13.2
通讯作者：
de Camargo, Zoilo Pires
中科院分区：
文献类型：
--
作者：
Rodrigues, Anderson Messias;Sybren de Hoog, G.;Zhang, Yu;de Camargo, Zoilo Pires
孢子丝菌病是由孢子丝菌属真菌引起的，在世界范围内都有发生，但传染性物种的分布并不均匀。孢子丝繁殖体通常通过受污染的植物碎片对皮肤造成的轻微创伤或通过携带疾病的猫科动物的抓伤或咬伤进入温血宿主，通常以爆发的形式。在过去的十年中，孢子丝菌病已从一种相对不起眼的地方性感染转变为一种流行的人畜共患健康问题。我们评估了猫科动物宿主对人类孢子丝菌病的流行病学、空间分布、患病率和遗传多样性的影响。核和线粒体标记揭示了巴西沙门氏菌和申克沙门氏菌种群之间巨大的结构遗传差异，表明宿主、病原体和环境的相互作用对孢子丝菌物种的多样性、频率和分布具有结构性影响。系统发育数据支持最近巴西蜥蜴的栖息地从植物到猫的转变，这种转变似乎发生在巴西东南部，并且是其出现的原因。在猫-人流行病的早期扩张阶段发现了克隆结构。然而，植物相关病原体申克沙门氏菌中普遍存在的重组结构产生了多种基因型，随着时间的推移，这些基因型作为人类感染的病原体的频率并未显示出任何显着增加。这些结果表明，密切相关的病原体在流行病中可以遵循不同的策略。因此，特定物种的传播类型可能需要不同的公共卫生策略来控制疾病。
Sporotrichosis, caused by agents of the fungal genus Sporothrix, occurs worldwide, but the infectious species are not evenly distributed. Sporothrix propagules usually gain entry into the warm-blooded host through minor trauma to the skin from contaminated plant debris or through scratches or bites from felines carrying the disease, generally in the form of outbreaks. Over the last decade, sporotrichosis has changed from a relatively obscure endemic infection to an epidemic zoonotic health problem. We evaluated the impact of the feline host on the epidemiology, spatial distribution, prevalence and genetic diversity of human sporotrichosis. Nuclear and mitochondrial markers revealed large structural genetic differences between S. brasiliensis and S. schenckii populations, suggesting that the interplay of host, pathogen and environment has a structuring effect on the diversity, frequency and distribution of Sporothrix species. Phylogenetic data support a recent habitat shift within S. brasiliensis from plant to cat that seems to have occurred in southeastern Brazil and is responsible for its emergence. A clonal structure was found in the early expansionary phase of the cat–human epidemic. However, the prevalent recombination structure in the plant-associated pathogen S. schenckii generates a diversity of genotypes that did not show any significant increase in frequency as etiological agents of human infection over time. These results suggest that closely related pathogens can follow different strategies in epidemics. Thus, species-specific types of transmission may require distinct public health strategies for disease control.
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影响因子：
6.7
作者：
James TY;Litvintseva AP;Vilgalys R;Morgan JA;Taylor JW;Fisher MC;Berger L;Weldon C;du Preez L;Longcore JE
通讯作者：
Longcore JE
影响因子：
10.7
作者：
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通讯作者：
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通讯作者：
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影响因子：
10.7
作者：
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通讯作者：
Standley DM
影响因子：
9.4
作者：
DIXON, DM;SALKIN, IF;COLES, FB
通讯作者：
COLES, FB