Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study.
Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study.
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增强的内侧前额叶皮层和海马活动可改善 APP/PS1 小鼠的记忆泛化：多模式动物 MRI 研究
DOI：
10.3389/fncel.2022.848967
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发表时间：
2022
影响因子：
5.3
通讯作者：
Tao J
中科院分区：
文献类型：
--
作者：
Liu W;Li J;Li L;Zhang Y;Yang M;Liang S;Li L;Dai Y;Chen L;Jia W;He X;Lin H;Tao J
记忆泛化允许个体将先前学习的运动模式扩展到类似的环境，有助于认知灵活性。在阿尔茨海默病（Alzheimer's disease，AD）中，概括障碍导致情景记忆的缺陷，导致AD患者忘记或放错东西，甚至失去回家的路。认知训练通过改变AD患者的思维方式和记忆灵活性，能有效改善AD患者的认知功能。本研究利用T型迷宫模拟APP/PS1小鼠的认知训练，以阐明认知训练后有益作用的潜在机制。我们发现，通过T形迷宫进行4周的认知训练可以提高APP/PS1小鼠的记忆概括能力。功能磁共振成像（fMRI）结果显示，认知训练后内侧前额叶皮层（mPFC）和海马的功能活动增强;磁共振波谱（MRS）结果显示，认知训练后内侧前额叶皮层、海马和丘脑返回核（Re）内N-乙酰天冬氨酸（NAA）和谷氨酸（Glu）的神经化学代谢增强。记忆概括实验中，mPFC和海马的功能活动与逃避潜伏期呈负相关。提示认知训练可能通过增强mPFC和海马的功能活动，增加mPFC、海马和Re核等脑区NAA和Glu的代谢，从而提高记忆概括能力。
Memory generalization allows individuals to extend previously learned movement patterns to similar environments, contributing to cognitive flexibility. In Alzheimer’s disease (AD), the disturbance of generalization is responsible for the deficits of episodic memory, causing patients with AD to forget or misplace things, even lose track of the way home. Cognitive training can effectively improve the cognition of patients with AD through changing thinking mode and memory flexibility. In this study, a T-shaped maze was utilized to simulate cognitive training in APP/PS1 mice to elucidate the potential mechanisms of beneficial effects after cognitive training. We found that cognitive training conducted by a T-shaped maze for 4 weeks can improve the memory generalization ability of APP/PS1 mice. The results of functional magnetic resonance imaging (fMRI) showed that the functional activity of the medial prefrontal cortex (mPFC) and hippocampus was enhanced after cognitive training, and the results of magnetic resonance spectroscopy (MRS) showed that the neurochemical metabolism of N-acetyl aspartate (NAA) and glutamic acid (Glu) in mPFC, hippocampus and reuniens (Re) thalamic nucleus were escalated. Furthermore, the functional activity of mPFC and hippocampus was negatively correlated with the escape latency in memory generalization test. Therefore, these results suggested that cognitive training might improve memory generalization through enhancing the functional activity of mPFC and hippocampus and increasing the metabolism of NAA and Glu in the brain regions of mPFC, hippocampus and Re nucleus.
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影响因子：
9.2
作者：
Preston, Alison R.;Eichenbaum, Howard
通讯作者：
Eichenbaum, Howard
影响因子：
4
作者：
Engvig, Andreas;Fjell, Anders M.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
6.8
作者：
Pedraza, Lizeth K.;Sierra, Rodrigo O.;Alvares, Lucas de Oliveira
通讯作者：
Alvares, Lucas de Oliveira