Interplay of hippocampus and prefrontal cortex in memory.

Interplay of hippocampus and prefrontal cortex in memory.
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DOI:
10.1016/j.cub.2013.05.041
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发表时间:
2013-09-09
期刊:
影响因子:
9.2
通讯作者:
Eichenbaum, Howard
Eichenbaum, Howard
中科院分区:
生物学1区
文献类型:
--
作者:
Preston, Alison R.;Eichenbaum, Howard

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最近对海马体和前额叶皮质的研究大大提高了我们对这些脑区在记忆编码和提取中的不同作用的理解,以及它们如何在将新记忆巩固到我们永久的知识仓库的漫长过程中相互作用。这些研究导致了一个新的模型,即海马体如何形成和重播记忆,前额叶皮质如何参与相关记忆发生的有意义的背景的表征,以及这些区域在记忆提取过程中如何相互作用。此外,他们还为海马体和前额叶皮质之间的相互作用如何支持将新记忆同化成称为图式的预先存在的知识网络,以及如何在这个过程中修改图式作为记忆巩固的基础提供了新的见解。
Recent studies on the hippocampus and the prefrontal cortex have considerably advanced our understanding of the distinct roles of these brain areas in the encoding and retrieval of memories, and of how they interact in the prolonged process by which new memories are consolidated into our permanent storehouse of knowledge. These studies have led to a new model of how the hippocampus forms and replays memories and how the prefrontal cortex engages representations of the meaningful contexts in which related memories occur, as well as how these areas interact during memory retrieval. Furthermore, they have provided new insights into how interactions between the hippocampus and prefrontal cortex support the assimilation of new memories into pre-existing networks of knowledge, called schemas, and how schemas are modified in this process as the foundation of memory consolidation.
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