Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.
Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.
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DOI：
10.1016/j.reprotox.2013.02.002
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Zoeller RT
中科院分区：
文献类型：
--
作者：
Vandenberg LN;Colborn T;Hayes TB;Heindel JJ;Jacobs DR Jr;Lee DH;Myers JP;Shioda T;Soto AM;vom Saal FS;Welshons WV;Zoeller RT
多年来，来自不同学科的科学家一直在研究内分泌干扰物(EDCs)对人类和野生动物健康和福祉的影响。一些研究特别侧重于低剂量的影响，即那些被认为对人类和/或动物安全的剂量。其他人则关注非单调剂量-反应曲线的存在。这些概念挑战了对EDC进行化学风险评估的方式。持续的讨论明确了仍然存在哪些争议和挑战。我们解决了其中的几个问题，包括为什么对内分泌细胞的研究和监管应该纳入内分泌原则；对低剂量效应的共识水平是什么；我们对非单调性的理解面临挑战；以及内分泌细胞是否已被证明会产生不良影响。这一讨论应有助于更好地了解这些问题，并允许就这些问题对风险评估的影响进行更多对话。
For years, scientists from various disciplines have studied the effects of endocrine disrupting chemicals (EDCs) on the health and wellbeing of humans and wildlife. Some studies have specifically focused on the effects of low doses, i.e. those in the range that are thought to be safe for humans and/or animals. Others have focused on the existence of non-monotonic dose-response curves. These concepts challenge the way that chemical risk assessment is performed for EDCs. Continued discussions have clarified exactly what controversies and challenges remain. We address several of these issues, including why the study and regulation of EDCs should incorporate endocrine principles; what level of consensus there is for low dose effects; challenges to our understanding of non-monotonicity; and whether EDCs have been demonstrated to produce adverse effects. This discussion should result in a better understanding of these issues, and allow for additional dialogue on their impact on risk assessment.
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影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
DOI：
10.1080/07315724.2004.10719428
发表时间：
2004-12-01
影响因子：
3.5
作者：
Barker, DJP
通讯作者：
Barker, DJP
影响因子：
10.4
作者：
Barr DB;Olsson AO;Wong LY;Udunka S;Baker SE;Whitehead RD;Magsumbol MS;Williams BL;Needham LL
通讯作者：
Needham LL
影响因子：
3.5
作者：
Arnold AP
通讯作者：
Arnold AP
影响因子：
2.7
作者：
Balls, Michael;Amcoff, Patric;Zuang, Valerie
通讯作者：
Zuang, Valerie