Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.
Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.
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DOI：
10.1111/j.1530-0277.2012.01809.x
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
McGue M
中科院分区：
文献类型：
--
作者：
Irons DE;Iacono WG;Oetting WS;McGue M
在醛脱氢酶2（ALDH 2）基因中，ALDH 2 *2等位基因在东亚人群中普遍存在，编码一种活性严重降低的酶，从而破坏酒精的正常代谢。ALDH 2 *2等位基因的拥有已被反复证明与酒精依赖风险降低和酒精使用减少有关。然而，相对较少的研究已经考虑是否ALDH 2多态性饮酒的影响程度与发育阶段，或不同的环境背景。在一个纵向评估的样本356通过青少年和年轻人的东亚血统，我们研究了ALDH 2基因型和饮酒行为的多种措施之间的关系随着时间的推移的进展。我们还试图确定非生物学父母和哥哥姐姐酒精使用和滥用的环境影响，以及越轨的同伴行为，是否缓和ALDH 2基因型对酒精使用的影响。在所有酒精使用的测量中，ALDH 2 *2等位基因拥有和减少饮酒之间的关联在青春期中期和成年早期之间从可忽略到中度。养父母酒精使用和滥用的综合指数在酒精使用的数量和频率以及酒精学的测量中一致地调节了ALDH 2 *2等位基因的保护作用，例如高父母酒精使用和滥用降低了ALDH 2 *2等位基因的保护作用，而低父母酒精使用和滥用增强了等位基因的作用。无论是一个综合指数的年长的兄弟姐妹酒精使用和滥用，也不越轨的同伴行为一直与ALDH 2基因型的影响。ALDH 2 *2等位基因的保护作用在青春期和青年期增加，并受到父母饮酒和滥用酒精的环境影响。因此，ALDH 2提供了一个模型系统，用于探索基因-环境相互作用的性质。
In the aldehyde dehydrogenase 2 (ALDH2) gene, the ALDH2*2 allele, prevalent in East Asian populations, encodes an enzyme with severely reduced activity, thereby disrupting the normal metabolism of alcohol. Possession of the ALDH2*2 allele has been repeatedly shown to be associated with lower risk for alcohol dependence, and reduced alcohol use. However, relatively few studies have considered whether the magnitude of the effect of ALDH2 polymorphism upon drinking is related to developmental stage, or varies by environmental context. In a longitudinally assessed sample of 356 adopted adolescents and young adults of East Asian descent, we examined the progression over time of the relationship between ALDH2 genotype and multiple measures of drinking behavior. We also sought to determine whether the environmental influences of non-biological parent and elder sibling alcohol use and misuse, as well as deviant peer behavior, moderated the effect of ALDH2 genotype upon alcohol use. Across all measures of alcohol use, the association between ALDH2*2 allele possession and reduced drinking went from negligible to moderate between mid-adolescence and early adulthood. A combined index of adoptive parent alcohol use and misuse consistently moderated the protective effect of the ALDH2*2 allele across measures of quantity and frequency of alcohol use, and symptomology, such that high parental alcohol use and misuse reduced the protective effect of the ALDH2*2 allele, while low parental alcohol use and misuse enhanced the effect of the allele. Neither a combined index of elder sibling alcohol use and misuse, nor deviant peer behavior were consistently related to the effect of ALDH2 genotype. The protective effect of the ALDH2*2 allele increases over the course of adolescence and young adulthood and is modified by the environmental influence of parental alcohol use and misuse. As such, ALDH2 provides a model system for exploring the nature of gene-environment interplay across development.
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影响因子：
7.2
作者：
McGue, M
通讯作者：
McGue, M
影响因子：
13.5
作者：
BOSRON, WF;LI, TK
通讯作者：
LI, TK
影响因子：
1.9
作者：
Li H;Borinskaya S;Yoshimura K;Kal'ina N;Marusin A;Stepanov VA;Qin Z;Khaliq S;Lee MY;Yang Y;Mohyuddin A;Gurwitz D;Mehdi SQ;Rogaev E;Jin L;Yankovsky NK;Kidd JR;Kidd KK
通讯作者：
Kidd KK
DOI：
10.1111/j.1530-0277.2009.00903.x
发表时间：
2009-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Hendershot CS;Collins SE;George WH;Wall TL;McCarthy DM;Liang T;Larimer ME
通讯作者：
Larimer ME
影响因子：
--
作者：
Hicks, Brian M.;South, Susan C.;DiRago, Ana C.;Iacono, William G.;McGue, Matt
通讯作者：
McGue, Matt