Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults.
Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults.
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DOI：
10.1111/j.1530-0277.2009.00903.x
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Larimer ME
中科院分区：
文献类型：
--
作者：
Hendershot CS;Collins SE;George WH;Wall TL;McCarthy DM;Liang T;Larimer ME
ALDH2和ADH 1B基因型与酒精使用的关联主要是使用病例对照研究进行评估的，这些研究通常侧重于成人样本和二分诊断结果。相对较少的研究评估了ALDH2和ADH 1B与持续饮酒结果或不同发育阶段的关系。这项研究在亚洲年轻人的混合性别样本中研究了ALDH 2和ADH 1B基因型对饮酒行为的加性和交互作用，重点是连续表型（例如，重度间歇性和危险性饮酒、酒精敏感性、饮酒后果），其表达预期先于酒精使用障碍的发作。样本包括182名年龄在18岁及以上（平均年龄= 20岁）的华裔和韩裔美国年轻人。使用广义线性模型估计ALDH2、ADH 1B和种族的影响。ALDH2*2等位基因预测较低的报告率的酒精使用和饮酒的后果，以及更大的报告酒精敏感性。饮酒结果存在显著的种族差异，例如朝鲜族预测饮酒率较高，酒精敏感性较低。ADH 1B状态与饮酒结果无显著相关。种族和ALDH2状态，而不是ADH 1B状态，始终解释了这个相对年轻的样本中酒精消费的显着差异。结果扩展了以前的工作，显示ALDH2基因型与饮酒后果的关联。研究结果进行了讨论的背景下，可能的发展和人口差异的影响ALDH2和ADH 1B的变化对酒精相关的表型。
Associations of ALDH2 and ADH1B genotypes with alcohol use have been evaluated largely using case–control studies, which typically focus on adult samples and dichotomous diagnostic outcomes. Relatively fewer studies have evaluated ALDH2 and ADH1B in relation to continuous drinking outcomes or at different developmental stages. This study examined additive and interactive effects of ALDH2 and ADH1B genotypes on drinking behavior in a mixed-gender sample of Asian young adults, focusing on continuous phenotypes (e.g., heavy episodic and hazardous drinking, alcohol sensitivity, drinking consequences) whose expression is expected to precede the onset of alcohol use disorders. The sample included 182 Chinese- and Korean-American young adults ages 18 years and older (mean age = 20 years). Effects of ALDH2, ADH1B and ethnicity were estimated using generalized linear modeling. The ALDH2*2 allele predicted lower reported rates of alcohol use and drinking consequences as well as greater reported sensitivity to alcohol. There were significant ethnic group differences in drinking outcomes, such that Korean ethnicity predicted higher drinking rates and lower alcohol sensitivity. ADH1B status was not significantly related to drinking outcomes. Ethnicity and ALDH2 status, but not ADH1B status, consistently explained significant variance in alcohol consumption in this relatively young sample. Results extend previous work by showing an association of ALDH2 genotype with drinking consequences. Findings are discussed in the context of possible developmental and population differences in the influence of ALDH2 and ADH1B variations on alcohol-related phenotypes.
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影响因子：
7.6
作者：
Hahm, HC;Lahiff, M;Guterman, NB
通讯作者：
Guterman, NB
DOI：
10.1097/01.alc.0000128239.87611.f5
发表时间：
2004-06-01
影响因子：
3.2
作者：
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作者：
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DOI：
10.1111/j.1530-0277.1996.tb01080.x
发表时间：
1996-05-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
--
作者：
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通讯作者：
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