Effects of butorphanol on feeding and neuropeptide Y in the rat.
Effects of butorphanol on feeding and neuropeptide Y in the rat.
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DOI：
10.1016/j.pbb.2011.08.010
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Levine AS
中科院分区：
文献类型：
--
作者：
Mitra A;Kotz CM;Kim EM;Grace MK;Kuskowski MA;Billington CJ;Levine AS
布托啡诺（[BT]，一种阿片受体激动剂/拮抗剂）与其他阿片受体激动剂的不同之处在于，单次给药BT可在饱食大鼠中引起高达12 g的食物摄入，而大多数阿片受体激动剂诱导轻度进食反应（2-3 g）。在这里，我们首先检查了BT引起进食的有效性是否受剂量、输注方法和给药后可能的快速耐受的影响。其次，我们研究了BT管理是否影响下丘脑NPY基因表达和肽水平。BT（4 mg/kg）单次给药在给药后2、3和6小时显著增加摄食量。然而，在重复注射4 mg/kg BT后，BT给药大鼠的累积长期摄入量与对照组无差异，表明动物通过在稍后时间减少进食来补偿BT注射后增加的进食。重复BT注射的递增剂量方案导致额外喂养。ARC中的NPY基因表达受食物摄入量的影响，但不受BT的影响。摄食量与NPY mRNA水平呈负相关。这与NPY在正常进食中的作用一致。BT治疗不影响NPY或瘦素RIA水平。我们的结论是，由BT产生的摄食是敏感的剂量和给药模式。此外，它的作用机制似乎不是由NPY或瘦素途径介导的。
Butorphanol ([BT] an opioid receptor agonist/antagonist) is different from other opioid agonists in that a single dose of BT can elicit up to 12 g of chow intake in a satiated rat whereas most opioid agonists induce a mild feeding response (2-3 g). Here, we first examined whether the effectiveness of BT to elicit feeding was affected by dose, method of infusion and possible tachyphylaxis following administration. Secondly, we examined whether BT administration influenced hypothalamic NPY gene expression and peptide levels. A single dose administration of BT (4 mg/kg) significantly increased food intake at 2, 3 and 6 hours after administration. However following repeated injections of BT at 4 mg/kg, the cumulative long-term intake of BT-treated rats did not differ from that of controls, indicating that the animals compensate for the increased feeding following BT injection by decreased feeding at a later time. An ascending dose schedule of repeated BT injections resulted in additional feeding. NPY gene expression in the ARC was influenced by how much food had been consumed, but not by BT. The amount of food consumed and the level of NPY mRNA were inversely correlated. This is consistent with NPY’s role in normal feeding. BT treatment did not affect either NPY or leptin RIA levels. We conclude that the feeding produced by BT is sensitive to dose and dosing paradigm. Further, its mechanism of action does not appear to be mediated by NPY or leptin pathways.
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影响因子：
2.9
作者：
Kim, EM;Shi, Q;Levine, AS
通讯作者：
Levine, AS
DOI：
10.1152/ajpregu.1996.271.1.r289
发表时间：
1996-07-01
影响因子：
2.8
作者：
Kotz, CM;Grace, MK;Levine, AS
通讯作者：
Levine, AS
影响因子：
3.6
作者：
RUDSKI, JM;SCHAAL, DW;LEVINE, AS
通讯作者：
LEVINE, AS
影响因子：
7.7
作者：
Schwartz, MW;Baskin, DG;Weigle, DS
通讯作者：
Weigle, DS
影响因子：
2.9
作者：
Pritchett, Carolyn E.;Pardee, Alicia L.;McGuirk, Sophia R.;Will, Matthew J.
通讯作者：
Will, Matthew J.