Control of stem cell fate by physical interactions with the extracellular matrix.

Control of stem cell fate by physical interactions with the extracellular matrix.
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DOI:
10.1016/j.stem.2009.06.016
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发表时间:
2009-07-02
期刊:
影响因子:
23.9
通讯作者:
Chen CS
Chen CS
中科院分区:
医学1区
文献类型:
--
作者:
Guilak F;Cohen DM;Estes BT;Gimble JM;Liedtke W;Chen CS

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A diverse array of environmental factors contribute to the overall control of stem cell activity. In particular, new data continues to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.
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