Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy.
Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy.
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DOI：
10.1126/sciadv.abc8098
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发表时间：
2020-10
期刊：
影响因子：
13.6
通讯作者：
Duff KE
中科院分区：
文献类型：
--
作者：
Fung CW;Guo J;Fu H;Figueroa HY;Konofagou EE;Duff KE
通过MRI评估的AD小鼠模型中tau病理学的扩散与脑组织体积减少相关，但与神经元损失无关。阿尔茨海默病（AD）中的Tau病理首先在内嗅皮层（EC）中发展，然后扩散到海马，接着是新皮层。总体而言，tau病理与神经变性和细胞损失相关性良好，但tau病理与结构变化或细胞损失相关的明显体积损失（萎缩）之间的空间和时间关联尚不清楚。使用体内磁共振成像（MRI）与基于张量的形态测量学（TBM），我们绘制了AD样进行性tau蛋白病小鼠模型中结构变化的时空模式。一种新的，在体内MRI图谱配准，然后应用于识别区域的内侧颞叶，有显着的体积减少。我们的研究表明，在tau蛋白病扩散的小鼠模型中，tau蛋白病从EC到海马的传播与TBM相关的萎缩相关，但齿状回和下托的萎缩先于明显的细胞损失。
Spread of tau pathology in a mouse model of AD assessed by MRI is associated with reduced brain tissue volume but not neuron loss. Tau pathology in Alzheimer’s disease (AD) first develops in the entorhinal cortex (EC), then spreads to the hippocampus, followed by the neocortex. Overall, tau pathology correlates well with neurodegeneration and cell loss, but the spatial and temporal association between tau pathology and overt volume loss (atrophy) associated with structural changes or cell loss is unclear. Using in vivo magnetic resonance imaging (MRI) with tensor-based morphometry (TBM), we mapped the spatiotemporal pattern of structural changes in a mouse model of AD-like progressive tauopathy. A novel, coregistered in vivo MRI atlas was then applied to identify regions in the medial temporal lobe that had a significant volume reduction. Our study shows that in a mouse model of tauopathy spread, the propagation of tau pathology from the EC to the hippocampus is associated with TBM-related atrophy, but atrophy in the dentate gyrus and subiculum precedes overt cell loss.
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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作者：
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