The association between tau PET and retrospective cortical thinning in clinically normal elderly.
The association between tau PET and retrospective cortical thinning in clinically normal elderly.
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Tau PET与临床正常老年人的回顾性皮质稀疏之间的关联。
DOI：
10.1016/j.neuroimage.2017.05.049
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发表时间：
2017-08-15
期刊：
影响因子：
5.7
通讯作者：
Schultz AP
中科院分区：
文献类型：
--
作者：
LaPoint MR;Chhatwal JP;Sepulcre J;Johnson KA;Sperling RA;Schultz AP
在尸检中，tau病理与神经元丢失有关，但tau病理和萎缩的时间演变仍不清楚。在这里，我们调查横断面的AV-1451-PET作为tau病理标志和皮质厚度之间的关联。我们还调查了在接受AV-1451扫描前三年的皮质变薄的回溯率，来自哈佛老年脑研究的103名老年人的临床正常队列。TAU测量采用几何转移矩阵、部分体积校正的标准化摄取值比率(SUVRs)和小脑灰质参照区。34个自由漂浮者定义的皮质感兴趣区(ROI)用于每个半球的厚度和AV-1451，另外还有7个体积ROI。我们研究了相同感兴趣区中的AV-1451和皮质厚度之间的“局部”关系，以及颞叶下部的AV-1451和所有厚度的ROI之间的关系。所有模型都包括基线年龄和性别，在纵向回溯性模型中，两者都与时间交互作用，作为协变量。控制两次扫描之间天数的横断面模型。横断面局部比较显示，AV-1451升高与较薄的皮质感兴趣区之间的显著关联主要发生在颞叶区域，而将较低的颞叶AV-1451与所有皮质感兴趣区相关联的分析则显示出广泛的显著关系模式，其中在颞叶和顶叶皮质的相关性最强。在我们的回溯性纵向分析中，我们看到了颞叶和顶叶区域的显著关系。在右侧颞骨上、中、颞极和梭形，以及左侧楔形和左侧颞叶上沟岸可见显著的局部关系。在右侧颞区(中、梭形)和双侧副海马皮层，发现下颞叶AV-1451与变薄的速度显著相关。我们观察到局部和下颞区的AV-1451信号与横断面皮质厚度以及外侧和内侧区域的减薄率之间存在显著的负相关。这是阐明tau病理与老年性和临床前阿尔茨海默病的纵向萎缩的关系的重要早期步骤。
Tau pathology has been associated with neuronal loss at autopsy, but the temporal evolution of tau pathology and atrophy remains unclear. Here, we investigate the association between cross-sectional AV-1451-PET as a marker of tau pathology and cortical thickness cross-sectionally. We also investigated retrospective rates of cortical thinning over the three years preceding the AV-1451 scan in a clinically normal cohort of 103 older adults from the Harvard Aging Brain Study. Tau measurements were Geometric Transfer Matrix partial volume corrected standardized uptake value ratios (SUVRs) with a cerebellar gray reference region. Thirty-four FreeSurfer-defined cortical regions of interest (ROIs) were used for both thickness and AV-1451 in each hemisphere, with seven additional volumetric ROIs. We examined “local” relationships between AV-1451 and cortical thickness in the same ROI, as well as inferior temporal AV-1451 and all thickness ROIs. All models included baseline age and sex, both interacting with time in retrospective longitudinal models, as covariates. Cross-sectional models controlled for the number of days between the two scans. Cross-sectional local comparisons revealed significant associations between elevated AV-1451 and thinner cortical ROIs predominantly in temporal regions, while analyses associating inferior temporal AV-1451 with all cortical ROIs showed a widespread pattern of significant relationships, which was strongest in temporal and parietal cortices. In our retrospective longitudinal analyses, we saw significant relationships in temporal and parietal regions. Significant local relationships were seen in right superior temporal, middle temporal, temporal pole, and fusiform, as well as the left cuneus and banks of the left superior temporal sulcus. Significant relationships between inferior temporal AV-1451 and faster thinning were observed in right temporal regions (middle temporal and fusiform) and bilateral parahippocampal cortices. We observed significant negative relationships between local and inferior temporal AV-1451 signal and both cross-sectional cortical thickness and rates of thinning in lateral and medial temporal regions. This is an important early step toward elucidating the relationship between tau pathology and retrospective longitudinal atrophy in aging and preclinical AD.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
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作者：
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通讯作者：
van der Flier, W. M.
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
9.9
作者：
ARRIAGADA, PV;GROWDON, JH;HYMAN, BT
通讯作者：
HYMAN, BT
影响因子：
4.2
作者：
Alcolea, Daniel;Vilaplana, Eduard;Fortea, Juan
通讯作者：
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