Serotonin modulates behavioral reactions to unfairness.

Serotonin modulates behavioral reactions to unfairness.
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DOI:
10.1126/science.1155577
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发表时间:
2008-06-27
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Robbins TW
Robbins TW
中科院分区:
其他
文献类型:
--
作者:
Crockett MJ;Clark L;Tabibnia G;Lieberman MD;Robbins TW

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5-羟色胺(5-HT)长期以来一直与社会行为和冲动有关,但它调节自我控制的机制仍不清楚。我们观察了操纵5-HT功能对最后通牒游戏中行为的影响,在最后通牒游戏中,玩家必须决定是否接受或拒绝另一个玩家的公平或不公平的金钱提议。5-HT水平耗尽的参与者拒绝了更大比例的不公平,但不公平的报价,没有表现出情绪,公平性判断,基本奖励处理或反应抑制的变化。我们的研究结果表明,5-HT在社会决策过程中的情绪调节中起着至关重要的作用。
Serotonin (5-HT) has long been implicated in social behavior and impulsivity, but the mechanisms through which it modulates self-control remain unclear. We observed the effects of manipulating 5-HT function on behavior in the Ultimatum Game, where players must decide whether to accept or reject fair or unfair monetary offers from another player. Participants with depleted 5-HT levels rejected a greater proportion of unfair, but not fair offers, without showing changes in mood, fairness judgments, basic reward processing or response inhibition. Our results suggest that 5-HT plays a critical role in regulating emotion during social decision-making.
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