Serotype, antigenicity, and pathogenicity of a naturally recombinant TW I genotype infectious bronchitis coronavirus in China.
Serotype, antigenicity, and pathogenicity of a naturally recombinant TW I genotype infectious bronchitis coronavirus in China.
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DOI：
10.1016/j.vetmic.2016.05.018
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发表时间：
2016-08-15
影响因子：
3.3
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Gao M;Wang Q;Zhao W;Chen Y;Zhang T;Han Z;Xu Q;Kong X;Liu S
天然重组TW I基因型代表了一种新的血清型。无论是商业疫苗还是减毒病毒都不能对天然重组TW I血清型的攻击提供完全的呼吸道保护。天然重组TW I血清型是非常致病的，并且能够在高百分比的鸟类中引起囊性输卵管。自2009年以来，自然重组TW I基因型传染性支气管炎病毒（IBV）毒株对中国家禽业造成了相当大的损害。为了更好地了解该基因型的抗原性和致病性，将ck/CH/LDL/140520毒株的特征与中国常用的四种商业IB疫苗株以及代表两种类型IBV毒株的四种减毒病毒的特征进行了比较，据信其起源于中国，并且是在中国和世界许多其它地方的鸡群中传播的主要IBV类型。结果表明，所有8个菌株的遗传和血清型不同的菌株ck/CH/LDL/140520。此外，疫苗株和减毒病毒都不能为鸡提供对抗ck/CH/LDL/140520毒株攻击的完全呼吸道保护，这表明有必要开发新的活疫苗或评估已建立的疫苗的联合使用来控制自然重组TW I型IBV毒株未来。我们的研究结果表明，菌株ck/CH/LDL/140520是非常致病性的，它能够导致高比例的鸡的囊性输卵管，以及由于肾炎和呼吸窘迫而导致的死亡，特别是在1日龄感染的鸡中。
The naturally recombinant TW I genotype represents a novel serotype. Neither the commercial vaccines nor the attenuated viruses could provide complete respiratory protection of chickens against a challenge with the naturally recombinant TW I serotype. The naturally recombinant TW I serotype is very pathogenic, and is able to cause cystic oviducts in a high percentage of birds. Since 2009, strains of the naturally recombinant TW I genotype of infectious bronchitis virus (IBV) have caused considerable damage to the Chinese poultry industry. To better understand the antigenicity and pathogenesis of this genotype, the characteristics of the ck/CH/LDL/140520 strain were compared to those of four commercial IB vaccine strains that are used commonly in China, as well as four attenuated viruses that represent two types of IBV strains, which are believed to have originated in China and are the predominant IBV types circulating in chicken flocks in China and many other parts of the world. The results showed that all eight strains were genetically and serotypically different from the strain ck/CH/LDL/140520. Furthermore, neither the vaccine strains nor the attenuated viruses could provide complete respiratory protection of chickens against a challenge with the ck/CH/LDL/140520 strain, indicating that it is necessary to develop new live vaccines or to evaluate the use of established vaccines in combination to control naturally recombinant TW I-type IBV strains in the future. Our results showed that strain ck/CH/LDL/140520 is very pathogenic, and that it is able to cause cystic oviducts in a high percentage of birds, as well as mortality due to nephritis and respiratory distress with complete tracheal ciliostasis, especially in chickens infected at 1 day of age.
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DOI：
10.1016/j.tvjl.2007.08.018
发表时间：
2009-01
期刊：
Veterinary journal (London, England : 1997)
影响因子：
--
作者：
Liu S;Zhang X;Wang Y;Li C;Liu Q;Han Z;Zhang Q;Kong X;Tong G
通讯作者：
Tong G
影响因子：
3.3
作者：
Liu X;Ma H;Xu Q;Sun N;Han Z;Sun C;Guo H;Shao Y;Kong X;Liu S
通讯作者：
Liu S
影响因子：
4.4
作者：
CRINION, RAP
通讯作者：
CRINION, RAP
影响因子：
3.3
作者：
Chen L;Zhang T;Han Z;Liang S;Xu Y;Xu Q;Chen Y;Zhao Y;Shao Y;Li H;Wang K;Kong X;Liu S
通讯作者：
Liu S
影响因子：
2.8
作者：
Xu, Qianqian;Han, Zongxi;Liu, Shengwang
通讯作者：
Liu, Shengwang