Evaluation of the protection conferred by commercial vaccines and attenuated heterologous isolates in China against the CK/CH/LDL/97I strain of infectious bronchitis coronavirus.
Evaluation of the protection conferred by commercial vaccines and attenuated heterologous isolates in China against the CK/CH/LDL/97I strain of infectious bronchitis coronavirus.
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DOI：
10.1016/j.tvjl.2007.08.018
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Tong G
中科院分区：
文献类型：
--
作者：
Liu S;Zhang X;Wang Y;Li C;Liu Q;Han Z;Zhang Q;Kong X;Tong G
鸡传染性支气管炎病毒（IBV）给世界范围内的养禽业造成了巨大的经济损失。该病毒的不同血清型几乎没有交叉保护作用。本研究基于S1基因比较以及接种商业疫苗和减毒同源和异源毒株提供的保护，研究了CK/CH/LDL/97 I型毒株和参考IBV之间的基因型关系。系统进化分析和S1序列比较表明，CK/CH/LDL/97 I型病毒可能是我国IBV疫苗株和其它毒株的一个新血清型。通过发病率、死亡率和病毒从攻毒雏鸡中的再分离来评价保护效力。IBV疫苗接种提供了完全的保护，但商业疫苗没有提供足够的呼吸保护。因此，研制CK/CH/LDL/97 I型IBV的特异性毒株和疫苗是控制鸡传染性支气管炎的必要条件。进一步开发减毒CK/CH/LDL/97 I菌株可能为实现这一目标做出有价值的贡献。
Avian infectious bronchitis virus (IBV) causes tremendous economic losses to the poultry industry worldwide. Different serotypes of this virus show little cross-protection. The present study investigated the genotypic relationship between CK/CH/LDL/97I-type strains and reference IBVs based on S1 gene comparisons and the protection provided by vaccination with commercial vaccines and attenuated homologous and heterologous strains. Phylogenetic analysis and the comparison of S1 showed that CK/CH/LDL/97I-type virus might be a new serotype compared to vaccine strains and other types of IBV isolates in China. Protection efficacy was evaluated by morbidity, mortality, and virus re-isolation from the challenged chicks. Complete protection by IBV vaccination was provided by the homologous strain but sufficient respiratory protection was not provided by the commercial vaccines. Heterologous strains against CK/CH/LDL/97I challenge and the development of a vaccine against CK/CH/LDL/97I-type IBV will be necessary to control infectious bronchitis disease in poultry. Further development of the attenuated CK/CH/LDL/97I strain may provide a valuable contribution towards this goal.
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