Cervico-vaginal mucus (CVM) - an accessible source of immunologically informative biomolecules.
Cervico-vaginal mucus (CVM) - an accessible source of immunologically informative biomolecules.
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DOI：
10.1007/s11259-018-9734-0
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发表时间：
2018-12
影响因子：
2.2
通讯作者：
O'Farrelly C
中科院分区：
文献类型：
--
作者：
Adnane M;Meade KG;O'Farrelly C
宫颈阴道粘液（CVM）是子宫、宫颈和阴道上皮细胞分泌的产物，有助于子宫润滑和微生物清除。CVM主要由水和粘蛋白组成，还含有高水平的免疫活性蛋白，如免疫球蛋白A（伊加），乳铁蛋白和溶菌酶，通过阻断粘附和介导微生物杀灭来防止感染。细胞因子、趋化因子和抗微生物肽的库主要由子宫内膜上皮细胞分泌到子宫腔中产生并集中在CVM中。这些炎性生物标志物的数量和相对比例受多种因素影响，包括动物的发情周期和健康状况，因此可能提供重要的诊断和预后指标。我们建议，测量牛CVM的分子特征可能是一个有用的方法来识别和监测肉牛和奶牛的生殖道病理。
Cervico-vaginal mucus (CVM), the product of epithelial cells lining the uterus, cervix and vagina, is secreted to facilitate uterine lubrication and microbial clearance. Predominantly composed of water and mucins, CVM also contains high levels of immuno-active proteins such as immunoglobulin A (IgA), lactoferrin and lysozyme which protect against infection by blocking adhesion and mediating microbial killing. The repertoire of cytokines, chemokines and antimicrobial peptides is predominantly generated by the secretions of endometrial epithelial cells into the uterine lumen and concentrated in the CVM. The quantity and relative proportions of these inflammatory biomarkers are affected by diverse factors including the estrus cycle and health status of the animal and therefore potentially provide important diagnostic and prognostic indicators. We propose that measuring molecular signatures in bovine CVM could be a useful approach to identifying and monitoring genital tract pathologies in beef and dairy cows.
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DOI：
10.1186/1477-7827-8-152
发表时间：
2010-12-22
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Gabler C;Fischer C;Drillich M;Einspanier R;Heuwieser W
通讯作者：
Heuwieser W
影响因子：
4.4
作者：
Davies, Darren;Meade, Kieran G.;Sheldon, I. Martin
通讯作者：
Sheldon, I. Martin
影响因子：
2.8
作者：
Dadarwal, Dinesh;Palmer, Colin;Griebel, Philip
通讯作者：
Griebel, Philip
影响因子：
1.9
作者：
Chapwanya, Aspinas;Meade, Kieran G.;O'Farrelly, Cliona
通讯作者：
O'Farrelly, Cliona
影响因子：
56.9
作者：
Corbin, Brian D.;Seeley, Erin H.;Skaar, Eric P.
通讯作者：
Skaar, Eric P.