High level of visfatin and the activation of Akt and ERK1/2 signaling pathways are associated with endometrium malignant transformation in polycystic ovary syndrome
High level of visfatin and the activation of Akt and ERK1/2 signaling pathways are associated with endometrium malignant transformation in polycystic ovary syndrome
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高水平visfatin及Akt、ERK1/2信号通路激活与多囊卵巢综合征子宫内膜恶变相关
DOI：
10.1080/09513590.2019.1650340
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发表时间：
2020-02
影响因子：
2
通讯作者：
Zhang Huiying
中科院分区：
文献类型：
--
作者：
Tian Wenyan;Zhang Huixia;Zhang Yan;Wang Yingmei;Zhang Yanfang;Xue Fengxia;Song Xueru;Zhang Huiying
摘要本研究旨在探讨多囊卵巢综合征（PCOS）患者血清内脂素水平及子宫内膜组织内脂素表达的临床病理意义。共80例PCOS患者和80例匹配的对照被纳入本研究。分析内脂素在PCOS患者子宫内膜中的表达与临床病理特征的关系。探讨内脂素与p-Akt、Akt、p-ERK 1/2、ERK 1/2在PCOS组织中表达的相关性。内脂素在PCOS子宫内膜组织中的表达显著高于对照组（p = 0.001）。PCOS患者子宫内膜组织中Akt和ERK 1/2的磷酸化表达明显高于对照组（p <0.05）。此外，PCOS组织中组织内脂素的高表达与p-Akt（p = 0.015）和p-ERK 1/2（p = 0.013）的表达呈正相关。Western blotting结果显示，内脂素在PCOS患者子宫内膜增生和癌变组织中的蛋白表达高于正常子宫内膜组织，差异有统计学意义（p = 0.027）。p-Akt（p = 0.018）和p-ERK 1/2（p = 0.035）在PCOS患者子宫内膜增生和子宫内膜癌中的表达显著高于正常子宫内膜组织。内脂素可能是PCOS患者子宫内膜恶变的潜在生物标志物。
Abstract This study aimed to assess the clinicopathological significance of serum levels and endometrium tissue expression of visfatin in polycystic ovary syndrome (PCOS) patients. A total of 80 PCOS patients and 80 matching controls were included in this study. We analyzed the relationship between the expression of visfatin in endometrium and clinicopathological characteristics in PCOS patients. The correlation between the expression of visfatin and p-Akt, Akt, p-ERK1/2, and ERK1/2 in PCOS tissues was evaluated as well. Visfatin expression in PCOS endometrial tissues were significantly higher than those in controls (p = .001). The expression of phosphorylation of Akt and ERK1/2 were significantly higher in PCOS endometrium tissues compared to controls (p < .05). Moreover, a high expression of tissue visfatin in PCOS tissues was positively correlated with the expression of p-Akt (p = .015), and p-ERK1/2 (p = .013). Western blotting revealed that protein expression of visfatin in PCOS patients with endometrial hyperplasia and cancer was higher than that in patients with normal endometrium tissues, and the difference was statistically significant (p = .027). The expression of p-Akt (p = .018) and p-ERK1/2 (p = .035) in PCOS patients with endometrial hyperplasia and cancer was significantly higher than that in patients with normal endometrium tissues. Visfatin may be a potential biomarker for endometrial malignant transformation in PCOS patients.
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影响因子：
3.8
作者：
Lee, Yi-Chen;Yang, Yi-Hsin;Yuan, Shyng-Shiou F.
通讯作者：
Yuan, Shyng-Shiou F.
影响因子：
--
作者：
Cymbaluk-Płoska A;Chudecka-Głaz A;Pius-Sadowska E;Sompolska-Rzechuła A;Machaliński B;Menkiszak J
通讯作者：
Menkiszak J
影响因子：
6.7
作者：
Teede HJ;Misso ML;Costello MF;Dokras A;Laven J;Moran L;Piltonen T;Norman RJ;International PCOS Network
通讯作者：
International PCOS Network
影响因子：
3.8
作者：
Kim, Jae Geun;Kim, Eun Ok;Lee, Byung Ju
通讯作者：
Lee, Byung Ju
影响因子：
3.5
作者：
Hufton, SE;Moerkerk, PT;Hoogenboom, HR
通讯作者：
Hoogenboom, HR