Circulating Serum Level of Visfatin in Patients with Endometrial Cancer.
Circulating Serum Level of Visfatin in Patients with Endometrial Cancer.
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DOI：
10.1155/2018/8576179
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发表时间：
2018
影响因子：
--
通讯作者：
Menkiszak J
中科院分区：
文献类型：
--
作者：
Cymbaluk-Płoska A;Chudecka-Głaz A;Pius-Sadowska E;Sompolska-Rzechuła A;Machaliński B;Menkiszak J
肥胖是导致包括子宫内膜癌在内的许多疾病的众所周知的因素。脂肪组织是异质的内分泌器官。内脏脂肪素是一种新发现的由脂肪组织产生的蛋白质。这项工作的目的是根据临床进展和组织病理学肿瘤分化来评估子宫内膜癌患者的内脏脂肪素血清水平浓度。基于 ROC 曲线下面积的分析，内脂素蛋白对高度分化（FIGO III 和 IV）与较低临床分期（FIGO I 和 II）的诊断能力以及细胞分化的预后程度（G1 与 G2、G2 与 G3）的诊断能力如下：0.87、0.81 和 0.86。相对于子宫内膜浸润深度 (p = 0.004) 以及肿瘤大小 (p = 0.003)，在血管侵犯 (p = 0.02) 和淋巴结转移 (p = 0.01) 的患者中观察到内脂素浓度显着升高。仅由于淋巴管的侵袭，内脏脂肪素血清浓度没有差异。 Visfatin 似乎是子宫内膜癌进展的良好标志物。高内脂素血清水平预示子宫内膜癌患者预后不良。
Obesity is a well-known factor that leads to many diseases including endometrial cancer. The adipose tissue is a heterogeneous organ of internal secretion. Visfatin is a newly discovered protein produced by fat tissues. The purpose of this work was to evaluate serum level concentrations of visfatin in patients with endometrial cancer based on clinical progression and histopathological tumor differentiation. The diagnostic capabilities of visfatin protein in high differentiation (FIGO III and IV) from a lower (FIGO I and II) clinical stage and prognostic degree of cell differentiation (G1 versus G2, G2 versus G3) on the basis of the analysis of the area under the ROC curve are as follows: 0.87, 0.81, and 0.86. Significantly higher concentrations of visfatin have been observed in patients with invasion of the blood vessels (p = 0.02) and lymph node metastases (p = 0.01) in reference to the depth of infiltration of the endometrium (p = 0.004), as well as the size of the tumor (p = 0.003). Visfatin serum concentrations did not differ due to the invasion of the lymphatic vessels only. Visfatin seems to be a good marker of endometrial cancer progress. High visfatin serum level predicts poor prognosis in endometrial cancer patients.
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影响因子：
168.9
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
通讯作者：
Zwahlen, Marcel
影响因子：
3.8
作者：
Lee, Yi-Chen;Yang, Yi-Hsin;Yuan, Shyng-Shiou F.
通讯作者：
Yuan, Shyng-Shiou F.
Visfatin 通过激活 PI3K/Akt 和 MAPK/ERK1/2 信号通路刺激子宫内膜癌细胞增殖
影响因子：
4.7
作者：
Wang, Yingmei;Gao, Chao;Xue, Fengxia
通讯作者：
Xue, Fengxia
影响因子：
4.6
作者：
Aune D;Sen A;Vatten LJ
通讯作者：
Vatten LJ
影响因子：
7.6
作者：
Jarrar, M. H.;Baranova, A.;Younossi, Z. M.
通讯作者：
Younossi, Z. M.