Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity.
Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity.
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DOI：
10.1155/2014/454696
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发表时间：
2014
影响因子：
3.1
通讯作者：
Winner B
中科院分区：
文献类型：
--
作者：
Regensburger M;Prots I;Winner B
在帕金森氏病(PD)和其他突触核病中，慢性神经变性发生在中枢神经系统的不同区域，导致进行性运动和非运动症状。目前可用的对症治疗方案并不能减缓或阻止疾病的进展。这突显了更好地了解疾病机制和疾病模型的必要性。新生神经元在成年海马区和脑室下区/嗅球系统中的产生受到许多不同调节因素的影响，并可能参与记忆处理、抑郁和嗅觉，这些症状在帕金森病中常见。人类帕金森病患者的成人神经源性生态位的病理机制仍然很难理解，但不同的临床前模型已经显示出成人神经发生的深刻变化。干细胞增殖、分化、存活以及轴突生长和脊柱形成的改变与帕金森病发病的不同方面有关。因此，成人大脑中的神经发生为研究疾病机制和化合物提供了一个理想的模型。此外，成年新生神经元被认为是内源性修复的来源。在这里，我们回顾了关于帕金森病成人神经源性生态位的现有知识，并强调了未来研究的领域。
In Parkinson's disease (PD) and other synucleinopathies, chronic neurodegeneration occurs within different areas of the central nervous system leading to progressive motor and nonmotor symptoms. The symptomatic treatment options that are currently available do not slow or halt disease progression. This highlights the need of a better understanding of disease mechanisms and disease models. The generation of newborn neurons in the adult hippocampus and in the subventricular zone/olfactory bulb system is affected by many different regulators and possibly involved in memory processing, depression, and olfaction, symptoms which commonly occur in PD. The pathology of the adult neurogenic niches in human PD patients is still mostly elusive, but different preclinical models have shown profound alterations of adult neurogenesis. Alterations in stem cell proliferation, differentiation, and survival as well as neurite outgrowth and spine formation have been related to different aspects in PD pathogenesis. Therefore, neurogenesis in the adult brain provides an ideal model to study disease mechanisms and compounds. In addition, adult newborn neurons have been proposed as a source of endogenous repair. Herein, we review current knowledge about the adult neurogenic niches in PD and highlight areas of future research.
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DOI：
10.1093/brain/awq079
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Bohnen NI;Müller ML;Kotagal V;Koeppe RA;Kilbourn MA;Albin RL;Frey KA
通讯作者：
Frey KA
影响因子：
8.6
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
通讯作者：
Del Dotto, Paolo
影响因子：
168.9
作者：
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通讯作者：
Destée, A
影响因子：
3.4
作者：
Couillard-Despres, Sebastien;Aigner, Ludwig
通讯作者：
Aigner, Ludwig
影响因子：
9.9
作者：
Abbott, RD;Petrovitch, H;Ross, GW
通讯作者：
Ross, GW