Basal and suppressed salivary cortisol in female Vietnam nurse veterans with and without PTSD.
Basal and suppressed salivary cortisol in female Vietnam nurse veterans with and without PTSD.
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DOI：
10.1016/j.psychres.2008.04.020
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发表时间：
2008-12-15
影响因子：
11.3
通讯作者：
Yehuda, Rachel
中科院分区：
文献类型：
--
作者：
Metzger, Linda J.;Carson, Margaret A.;Lasko, Natasha B.;Paulus, Lynn A.;Orr, Scott P.;Pitman, Roger K.;Yehuda, Rachel
已经表明，关于低基础皮质醇水平和在PTSD中响应于地塞米松（DEX）给药的皮质醇抑制增强的不一致发现可能反映了性别、创伤类型、创伤发生时的发展阶段（例如，儿童期与成年期）、早期创伤前风险因素或其他个体差异。这项研究检查了上午8点和下午4点的唾液皮质醇水平，以及40名女性越南护士退伍军人对0.5 mg DEX的皮质醇反应，这些退伍军人患有慢性PTSD（当前），而43名从未患有PTSD（从未）。重复测量的协方差分析没有发现显着的组间差异，皮质醇水平或皮质醇抑制。鉴于在越南服役的护士与先前研究的男性越南战斗退伍军人有相似的暴露，暴露年龄和暴露持续时间，目前缺乏证据表明患有PTSD的护士中皮质醇低和皮质醇过度抑制，表明先前在男性越南退伍军人，女性儿童性虐待，而其他人群可能反映了不仅仅是创伤后应激障碍的风险因素。
It has been suggested that discrepant findings regarding low basal cortisol levels and enhanced suppression of cortisol in response to dexamethasone (DEX) administration in PTSD may reflect individual differences in gender, trauma type, stage of development at trauma occurrence (e.g., childhood vs. adulthood), early pre-traumatic risk factors, or other individual differences. This study examined salivary cortisol levels at 8:00 a.m. and 4:00 p.m. as well as cortisol response to 0.5 mg DEX in 40 female Vietnam nurse veterans who had current, chronic PTSD (Current) vs. 43 who never had PTSD (Never). Repeated measures analyses of covariance did not reveal significant group differences in cortisol levels or cortisol suppression. Given that nurses who served in Vietnam had similar exposures, ages at exposure, and duration since exposure to previously studied male Vietnam combat veterans, the present lack of evidence for low cortisol and cortisol hyper-suppression in nurses with PTSD suggests that previous findings of low cortisol and cortisol hyper-suppression in male Vietnam veterans, females sexually abused as children, and other populations may reflect risk factors beyond simply having PTSD.
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