Wheel running decreases the positive reinforcing effects of heroin.

Wheel running decreases the positive reinforcing effects of heroin.
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DOI:
10.1016/s1734-1140(12)70891-5
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发表时间:
2012
影响因子:
4.4
通讯作者:
Pitts, Elizabeth G.
Pitts, Elizabeth G.
中科院分区:
医学3区
文献类型:
--
作者:
Smith, Mark A.;Pitts, Elizabeth G.

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本研究的目的是检查自愿跑轮对具有既定自我给药史的大鼠海洛因的积极增强作用的影响。大鼠被分配到久坐(无轮)和运动(轮)条件下,并接受训练以在积极强化意外情况下自我施用可卡因。然后在每日测试期间用不同剂量的海洛因对自我施用可卡因的大鼠进行测试。久坐的老鼠比运动的老鼠自行注射更多的海洛因,这种效应在低剂量和中等剂量的海洛因时最为明显。这些数据表明,自愿跑轮会降低海洛因的积极强化作用。
The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration. Rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. Rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions. Sedentary rats self-administered more heroin than exercising rats, and this effect was greatest at low and moderate doses of heroin. These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin.
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