Assessment of Functional Mobility After COVID-19 in Adults Aged 50 Years or Older in the Canadian Longitudinal Study on Aging.
Assessment of Functional Mobility After COVID-19 in Adults Aged 50 Years or Older in the Canadian Longitudinal Study on Aging.
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DOI：
10.1001/jamanetworkopen.2021.46168
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发表时间：
2022-01-04
影响因子：
13.8
通讯作者：
Canadian Longitudinal Study on Aging (CLSA) Team
中科院分区：
文献类型：
--
作者：
Beauchamp MK;Joshi D;McMillan J;Erbas Oz U;Griffith LE;Basta NE;Kirkland S;Wolfson C;Raina P;Canadian Longitudinal Study on Aging (CLSA) Team
在2020年最初的大流行封锁期间，COVID-19诊断与社区生活的中年和老年加拿大人的流动性和身体功能之间有什么联系？这项对24114名参与者进行的队列研究发现，与未患COVID-19的成年人相比，社区生活的中老年确诊、可能或疑似COVID-19患者的活动能力和身体功能恶化的几率高出近2倍，尽管大多数COVID-19参与者患有轻度至中度疾病且未住院。这些研究结果表明，与未患COVID-19的人相比，主要未住院的轻度和中度COVID-19患者的功能活动能力存在缺陷。这项队列研究评估了加拿大50岁或以上成年人的人群样本中轻度至中度COVID-19与移动性和身体功能变化的相关性。在2020年实施的疫情控制措施的影响之外，不需要住院的COVID-19与社区居住成年人的功能性活动之间的联系仍有待阐明。评估COVID-19诊断与加拿大50岁或以上成年人在最初大流行封锁期间的活动性和身体功能变化之间的关联。这项基于人群的队列研究使用了加拿大老龄化纵向研究（CLSA）COVID-19研究的数据。本研究于2020年4月15日启动，退出问卷于2020年9月至12月完成。还使用了里昂证券首次随访（2015 - 2018年）的大流行前数据。受访者包括居住在加拿大各省的中老年社区居民。数据分析时间为2021年2月至5月。对自我报告的COVID-19状态的评估改编自加拿大公共卫生署和疾病控制和预防中心在数据收集时可用的病例定义;病例被分类为确诊或可能、疑似或非COVID-19。自2019冠状病毒病疫情开始以来的流动性变化已使用2019冠状病毒病退出问卷中的流动性变化量表的全球评级进行评估。还检查了受试者报告的3项身体功能任务的新发困难。在基线时的51338名参与者中，21491名参与者（41.9%）为65岁或以上，26155名参与者（51.0%）为女性，25183名参与者（49.1%）为男性。在2748名确诊或可能或疑似COVID-19患者中，113人（94.2%）未住院。确诊或可能患有COVID-19的个人在从事家庭活动的能力方面流动性恶化的可能性更高（比值比[OR]，1.89; 95% CI，1.11 - 3.22），体力活动（OR，1.91; 95%CI，1.32 - 2.76），以及坐在椅子上后站立（OR，2.33; 95%CI，1.06 - 5.11），与同一大流行时期未患COVID-19的成年人相比。对于疑似COVID-19状态也发现了类似的结果（例如，家庭活动：OR，2.09; 95% CI，1.82 - 2.41）。这项在加拿大老年人中进行的队列研究发现，即使在没有住院的情况下，接受COVID-19诊断也与行动能力和功能结果恶化显著相关。这些发现表明，对于不需要住院治疗的轻度至中度COVID-19患者，可能需要进行干预。
What is the association of a COVID-19 diagnosis and mobility and physical function among community-living middle-aged and older Canadians during the initial pandemic lockdown in 2020? This cohort study of 24 114 participants found that community-living middle-aged and older adults with confirmed, probable, or suspected COVID-19 had nearly 2-fold higher odds of worsening mobility and physical function compared with adults without COVID-19, although most participants with COVID-19 had mild to moderate disease and were not hospitalized. These findings suggest that individuals with mild and moderate COVID-19 who were predominantly not hospitalized experienced deficits in functional mobility compared with those without COVID-19. This cohort study evaluates the association of mild to moderate COVID-19 with change in mobility and physical function in a population-based sample of adults aged 50 years or older in Canada. The association of COVID-19 not requiring hospitalization with functional mobility in community-dwelling adults above and beyond the impact of the pandemic control measures implemented in 2020 remains to be elucidated. To evaluate the association between a COVID-19 diagnosis and change in mobility and physical function of adults in Canada aged 50 years or older during the initial pandemic lockdown. This population-based cohort study used data from the Canadian Longitudinal Study on Aging (CLSA) COVID-19 study. This study was launched on April 15, 2020, and the exit questionnaires were completed between September and December 2020. Prepandemic data from the first CLSA follow-up (2015-2018) were also used. Respondents included middle-aged and older community-dwelling participants residing in Canadian provinces. Data were analyzed from February to May 2021. The assessment for self-reported COVID-19 status was adapted from the Public Health Agency of Canada and the Centers for Disease Control and Prevention case definition available at the time of data collection; cases were classified as confirmed or probable, suspected, or non–COVID-19. Changes in mobility since the start of the COVID-19 pandemic were assessed using global rating of change in mobility scales at the COVID-19 exit questionnaire. Participant-reported new onset of difficulty in 3 physical function tasks was also examined. Among 51 338 participants at baseline, 21 491 participants (41.9%) were 65 years or older and 26 155 participants (51.0%) were women and 25 183 (49.1%) were men. Of 2748 individuals with confirmed or probable or suspected COVID-19, 113 (94.2%) were not hospitalized. Individuals with confirmed or probable COVID-19 had higher odds of worsening mobility in terms of ability to engage in household activity (odds ratio [OR], 1.89; 95% CI, 1.11-3.22), physical activity (OR, 1.91; 95% CI, 1.32-2.76), and standing up after sitting in a chair (OR, 2.33; 95% CI, 1.06-5.11) compared with adults without COVID-19 during the same pandemic time period. Similar results were found for suspected COVID-19 status (eg, household activity: OR, 2.09; 95% CI, 1.82-2.41). This cohort study among older adults in Canada found that receiving a COVID-19 diagnosis was significantly associated with worse mobility and functioning outcomes even in the absence of hospitalization. These findings suggest that interventions may be needed for individuals with mild to moderate COVID-19 who do not require hospitalization.
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影响因子：
2.6
作者：
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通讯作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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