Altered time course of amygdala activation during speech anticipation in social anxiety disorder.
Altered time course of amygdala activation during speech anticipation in social anxiety disorder.
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DOI：
10.1016/j.jad.2016.11.014
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发表时间：
2017-02
影响因子：
6.6
通讯作者：
Craske MG
中科院分区：
文献类型：
--
作者：
Davies CD;Young K;Torre JB;Burklund LJ;Goldin PR;Brown LA;Niles AN;Lieberman MD;Craske MG
夸大的预期焦虑在社交焦虑障碍（SAD）中很常见。神经影像学研究显示，SAD患者对社会刺激的反应改变了神经活动，但很少有研究检查SAD患者在预期恐惧的社会刺激时的神经活动。本研究探讨了社交焦虑个体和健康对照（HC）在言语预期过程中威胁处理脑区活动的时间进程和幅度。参与者（SAD n = 58; HC n = 16）进行了功能磁共振成像（fMRI），在此期间，他们完成了90秒的控制预期任务和90秒的语音预期任务。重复测量多层次建模分析被用来检查组的差异，在时间过程中的活动，在讲话与控制预期的利益，包括双边杏仁核，杏仁核，腹侧纹状体，背侧前扣带皮层。与HC相比，SAD参与者的杏仁核活动的时间过程更长，在整个语音预期中变化更小，而杏仁核反应的整体幅度在组间没有差异。在其他关注区域，各组之间的活动幅度和时间过程基本相似。分析仅限于感兴趣的区域，由于欺骗指令的性质，参与者的任务顺序是相同的。持续的杏仁核时间过程中的预期可能唯一反映了高度检测的威胁或赤字的情绪调节在社会焦虑的个人。研究结果强调了检查杏仁核反应的时间动态的重要性。
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Repeated measures multi-level modeling analyses were used to examine group differences in time course activity during speech vs. control anticipation for regions of interest, including bilateral amygdala, insula, ventral striatum, and dorsal anterior cingulate cortex. The time course of amygdala activity was more prolonged and less variable throughout speech anticipation in SAD participants compared to HCs, whereas the overall magnitude of amygdala response did not differ between groups. Magnitude and time course of activity was largely similar between groups across other regions of interest. Analyses were restricted to regions of interest and task order was the same across participants due to the nature of deception instructions. Sustained amygdala time course during anticipation may uniquely reflect heightened detection of threat or deficits in emotion regulation in socially anxious individuals. Findings highlight the importance of examining temporal dynamics of amygdala responding.
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