Cigarette smoking status alters dysbiotic gut microbes in hypertensive patients.
Cigarette smoking status alters dysbiotic gut microbes in hypertensive patients.
复制标题
吸烟状况改变高血压患者的肠道菌群失调
DOI：
10.1111/jch.14298
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Wang P;Dong Y;Jiao J;Zuo K;Han C;Zhao L;Ding S;Yang X;Chen M;Li J
以往的研究表明，吸烟不仅是高血压（HTN）最重要的危险因素之一，而且还会改变肠道菌群（GM）的组成。尽管 GM 失调与 HTN 有关，但吸烟状态下的 HTN 患者中 GM 如何发生变化仍不清楚。本研究旨在探讨患有高血压的吸烟者（S-HTN）、患有高血压的非吸烟者（NS-HTN）和不患有高血压的吸烟者（S-CTR）之间肠道微生物群的差异，并确定吸烟是否会导致高血压患者的肠道微生物群紊乱。对没有 HTN 的非吸烟者（NS-CTR，n = 9）、S-CTR（n = 9）、NS-HTN（n = 18）和 S-HTN（n = 23）进行了粪便样本宏基因组测序分析。与S-CTR或NS-HTN相比，S-HTN的GM无序，在属和种水平上微生物α多样性较低，轴上的β多样性与S-CTR相比差异显着。 S-HTN 的微生物肠道型倾向于普雷沃氏菌为主。在 S-HTN 中观察到肠道属和物种组成发生显着变化，包括 Phycisphaera 和 Clostridium asparagiforme 的富集减少。此外，S-HTN 的肠道功能也发生了改变。因此，本研究的结果揭示了 S-HTN 中的 GM 紊乱，并阐明了吸烟在损害 HTN 肠道微生物组中的作用。烟草控制对于改善高血压患者的 GM 尤其重要，并且可能有益于预防未来的心血管事件。
Smoking not only is one of the most important risk factors of hypertension (HTN), but also alters the composition of gut microbiota (GM) in previous studies. Although dysbiosis of GM has been implicated in HTN, how GM alters in patients with HTN under smoking status is still not clear. This study aimed to explore the difference in intestinal microflora among smokers with HTN (S‐HTN), nonsmokers with HTN (NS‐HTN), and smokers without HTN (S‐CTR) and identify whether cigarette smoking led to disordered intestinal microbiota in patients with HTN. Metagenomic sequencing analysis of fecal specimens was conducted in nonsmokers without HTN (NS‐CTR, n = 9), S‐CTR (n = 9), NS‐HTN (n = 18), and S‐HTN (n = 23). Compared with S‐CTR or NS‐HTN, the GM in S‐HTN was disordered, with lower microbial α‐diversity and significant difference of β‐diversity on axes as compared to S‐CTR at genus and species level. The microbial enterotype in S‐HTN was inclined to Prevotella‐dominant type. Dramatic changes in the intestinal genera and species composition were observed in S‐HTN, including reduced enrichment of Phycisphaera and Clostridium asparagiforme. Moreover, the intestinal function altered in S‐HTN. Therefore, the findings of the present study revealed GM disorders in S‐HTN and clarified the role of smoking in impairing the intestinal microbiome in HTN. Tobacco control is particularly important for improving GM in patients with HTN, and might be beneficial in preventing future cardiovascular events.
登录
查看更多内容
影响因子：
37.8
作者：
Conen D;Tedrow UB;Koplan BA;Glynn RJ;Buring JE;Albert CM
通讯作者：
Albert CM
影响因子：
20.1
作者：
Kelly TN;Bazzano LA;Ajami NJ;He H;Zhao J;Petrosino JF;Correa A;He J
通讯作者：
He J
影响因子：
3.7
作者：
Chen W;Liu F;Ling Z;Tong X;Xiang C
通讯作者：
Xiang C
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
37.8
作者：
Lloyd-Jones, DM;Larson, MG;Levy, D
通讯作者：
Levy, D