Nuclear distribution of RNA polymerase II and mRNA processing machinery in early mammalian embryos.

Nuclear distribution of RNA polymerase II and mRNA processing machinery in early mammalian embryos.
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DOI:
10.1155/2014/681596
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发表时间:
2014
影响因子:
--
通讯作者:
Bogolyubov DS
Bogolyubov DS
中科院分区:
生物学3区
文献类型:
--
作者:
Bogolyubova IO;Bogolyubov DS

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核代谢组分的空间分布对基因表达过程的调控具有重要影响。虽然在哺乳动物体细胞中已经对关键核抗原的分布及其与核结构域的关联进行了彻底的追踪,但在胚胎着床前的类似数据却很少且不完整。然而,卵裂期的特点是伴随着合子基因的激活而发生最剧烈和最动态的核重组。在这篇综述中,我们试图总结在哺乳动物早期胚胎中进行的有关RNA聚合酶ii依赖性转录,pre-mRNA剪接mRNA输出的主要因子分布的研究结果。
Spatial distribution of components of nuclear metabolism provides a significant impact on regulation of the processes of gene expression. While distribution of the key nuclear antigens and their association with the defined nuclear domains were thoroughly traced in mammalian somatic cells, similar data for the preimplantation embryos are scanty and fragmental. However, the period of cleavage is characterized by the most drastic and dynamic nuclear reorganizations accompanying zygotic gene activation. In this minireview, we try to summarize the results of studies concerning distribution of major factors involved in RNA polymerase II-dependent transcription, pre-mRNA splicing mRNA export that have been carried out on early embryos of mammals.
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