SARS-CoV-2 Infection: New Molecular, Phylogenetic, and Pathogenetic Insights. Efficacy of Current Vaccines and the Potential Risk of Variants.
SARS-CoV-2 Infection: New Molecular, Phylogenetic, and Pathogenetic Insights. Efficacy of Current Vaccines and the Potential Risk of Variants.
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DOI：
10.3390/v13091687
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发表时间：
2021-08-25
期刊：
影响因子：
--
通讯作者：
Contini C
中科院分区：
文献类型：
--
作者：
Rotondo JC;Martini F;Maritati M;Mazziotta C;Di Mauro G;Lanzillotti C;Barp N;Gallerani A;Tognon M;Contini C
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 是一种新发现的冠状病毒，导致 2019 年冠状病毒病 (COVID-19) 大流行。 COVID-19 已迅速成为国际关注的突发公共卫生事件。尽管自大流行开始以来已经取得了显着的科学成就，但对这种新型冠状病毒的分子和致病特征以及人畜共患潜力方面的了解仍然相对有限。如今，一种疫苗，或者更确切地说是几种疫苗，在困扰人类的高传染性传染病史上首次在短短一年内生产出来。目前，有四种疫苗已获得监管机构许可，它们使用 RNA 或病毒载体技术。世界许多地方都感受到了疫苗接种运动的积极影响，但这种新感染的消失还远未成为现实，因为它还受到新型 SARS-CoV-2 变种的威胁，这种变种可能会破坏疫苗的有效性，阻碍免疫控制工作。事实上，目前的研究结果表明 SARS-CoV-2 正在更有效地适应人类传播，但应考虑与最初原型的进一步分歧。在这篇综述中，我们的目的是提供有关 SARS-CoV-2 的分子、系统发育和发病机制见解的当前知识集合。重点介绍了关于新出现的 SARS-CoV-2 变体的影响以及疫苗的开发和实施的最新发现。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 has rapidly become a public health emergency of international concern. Although remarkable scientific achievements have been reached since the beginning of the pandemic, the knowledge behind this novel coronavirus, in terms of molecular and pathogenic characteristics and zoonotic potential, is still relatively limited. Today, there is a vaccine, or rather several vaccines, which, for the first time in the history of highly contagious infectious diseases that have plagued mankind, has been manufactured in just one year. Currently, four vaccines are licensed by regulatory agencies, and they use RNA or viral vector technologies. The positive effects of the vaccination campaign are being felt in many parts of the world, but the disappearance of this new infection is still far from being a reality, as it is also threatened by the presence of novel SARS-CoV-2 variants that could undermine the effectiveness of the vaccine, hampering the immunization control efforts. Indeed, the current findings indicate that SARS-CoV-2 is adapting to transmission in humans more efficiently, while further divergence from the initial archetype should be considered. In this review, we aimed to provide a collection of the current knowledge regarding the molecular, phylogenetic, and pathogenetic insights into SARS-CoV-2. The most recent findings obtained with respect to the impact of novel emerging SARS-CoV-2 variants as well as the development and implementation of vaccines are highlighted.
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影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
6.4
作者：
Angelini MM;Akhlaghpour M;Neuman BW;Buchmeier MJ
通讯作者：
Buchmeier MJ
影响因子：
5.6
作者：
Contini, Carlo;Rotondo, John C.;Martini, Fernanda
通讯作者：
Martini, Fernanda
影响因子：
56.9
作者：
Chandrashekar, Abishek;Liu, Jinyan;Barouch, Dan H.
通讯作者：
Barouch, Dan H.