Reliability of neural activation and connectivity during implicit face emotion processing in youth.
Reliability of neural activation and connectivity during implicit face emotion processing in youth.
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DOI：
10.1016/j.dcn.2018.03.010
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发表时间：
2018-06
影响因子：
4.7
通讯作者：
Brotman MA
中科院分区：
文献类型：
--
作者：
Haller SP;Kircanski K;Stoddard J;White LK;Chen G;Sharif-Askary B;Zhang S;Towbin KE;Pine DS;Leibenluft E;Brotman MA
面部情绪成像范式在健康人群和精神病人群中都有广泛的应用。在这里，我们评估了儿童和青少年在广泛使用的内隐面孔情绪处理任务（即性别标签）上的血氧水平依赖（BOLD）激活和基于任务的功能连接的测试-重测可靠性。25名健康青年（M年龄 = 13.97 岁 s； 60%为女性）间隔约两个月完成两次功能磁共振成像（fMRI）扫描。参与者确定了显示愤怒、恐惧、快乐和中性情绪的面孔的性别。类内相关的贝叶斯适应（ICC）评估了任务事件与基线的诱发BOLD激活和基于杏仁核种子的功能连接的可靠性，以及面部情绪之间的对比。对于每一种面部情绪与基线，激活的良好可靠性在包括中、中、下额回在内的关键情绪处理区域被证明。然而，面部情绪之间的对比产生了不同的结果。愤怒脸、中性脸或快乐脸的对比显示，杏仁核与前额叶区域的连接具有良好的可靠性。恐惧脸和快乐脸的对比显示了前扣带激活的良好可靠性。研究结果为可重复性文献提供了信息，并强调了继续评估任务可靠性的必要性。
Face emotion imaging paradigms are widely used in both healthy and psychiatric populations. Here, in children and adolescents, we evaluate the test-retest reliability of blood oxygenation-level dependent (BOLD) activation and task-based functional connectivity on a widely used implicit face emotion processing task (i.e., gender labeling). Twenty-five healthy youth (M age = 13.97 year s; 60% female) completed two functional magnetic resonance imaging (fMRI) scan sessions approximately two months apart. Participants identified the gender of faces displaying angry, fearful, happy, and neutral emotions. A Bayesian adaptation of the intraclass correlation (ICC) assessed reliability of evoked BOLD activation and amygdala seed-based functional connectivity on task events vs. baseline as well as contrasts between face emotions. For each face emotion vs. baseline, good reliability of activation was demonstrated across key emotion processing regions including middle, medial, and inferior frontal gyri. However, contrasts between face emotions yielded variable results. Contrasts of angry to neutral or happy faces exhibited good reliability of amygdala connectivity to prefrontal regions. Contrasts of fearful to happy faces exhibited good reliability of activation in the anterior cingulate. Findings inform the reproducibility literature and emphasize the need for continued evaluation of task reliability.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
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影响因子：
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通讯作者：
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