Clinical usefulness of anti-muscarinic type 3 receptor autoantibodies in patients with primary Sjögren's syndrome.
Clinical usefulness of anti-muscarinic type 3 receptor autoantibodies in patients with primary Sjögren's syndrome.
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DOI：
10.55563/clinexprheumatol/gy6udz
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发表时间：
2021-07
影响因子：
3.7
通讯作者：
Cha S
中科院分区：
文献类型：
--
作者：
Mona M;Mondello S;Hyon JY;Saleh W;Han K;Lee HJ;Ha YJ;Kang EH;Lee YJ;Cha S
在抗M3 R研究的最大队列中阐明抗M3 R在干燥综合征（SS）中的临床价值。使用我们改良的On-Cell-Western分析筛选了361名受试者（156名原发性SS [pSS]，62名非SS干燥症[SICCA]，40名系统性红斑狼疮[SLE]，50名类风湿性关节炎[RA]和53名健康对照[HC]）的血浆。还分析了pSS（n=37）与SICCA（n=26）的唾液。确定抗M3 R的敏感性/特异性及其与综合临床/实验室特征的相关性。与其他组相比，pSS患者的血浆抗M3 R较高，区分pSS的诊断能力为良好至极好，特异性为85%，敏感性为75%至98%。pSS血浆抗M3 R与眼染色评分、抗Ro/SSA、IgG、β2-微球蛋白、ESR、ESSDAI呈正相关。与WBC、C4和唾液闪烁指数呈负相关。pSS患者唾液抗M3 R抗体是SICCA患者的3.59倍。有趣的是，血浆抗M3 R阳性（有或无抗Ro/SSA）在未接受唇活检的患者中高于接受活检的患者（分别为100% vs. 88.6%，p=0.013和90.6% vs. 75%，p=0.023）。2002年美国-欧洲-瑞士-组标准与用血浆抗-M3 R替代的标准之间的一致性达到92%，显著kappa值为0.824。抗M3 R增强了SS诊断的敏感性和特异性，与眼干燥和腺体功能减退以及ESSDAI的血液学/生物学领域相关。我们的研究结果还强调了SS诊断中的抗M3 R，其中多学科专家的临床评估，如唇活检，唾液测量或眼部评估是有限的。
To elucidate the clinical values of anti-M3R in Sjögren’s syndrome (SS) in the largest cohort for an anti-M3R study. The plasma of 361 subjects (156 primary-SS[pSS], 62 non-SS-sicca[SICCA], 40 systemic lupus erythematosus [SLE], 50 rheumatoid arthritis[RA], and 53 healthy controls[HC]) was screened using our modified On-Cell-Western assay. Saliva from pSS (n=37) compared to SICCA (n=26) was also analyzed. The sensitivity/specificity of anti-M3R and its association with comprehensive clinical/laboratory features were determined. Plasma-anti-M3R was higher in pSS compared to other groups, differentiating pSS with good-to-excellent diagnostic power with a specificity of 85% and a sensitivity between 75% and 98%. pSS plasma-anti-M3R was positively correlated with ocular staining scores, anti-Ro/SSA, IgG, β2-microglobulin, ESR, and ESSDAI. It was negatively correlated with WBC, C4, and salivary scintigraphic indices. Saliva-anti-M3R was 3.59 times higher in pSS than in SICCA. Interestingly, the positivity of plasma-anti-M3R with or without anti-Ro/SSA was higher in those who did not undergo a lip biopsy than in individuals with a biopsy (100% vs. 88.6%, p=0.013, and 90.6% vs. 75%, p=0.023, respectively). The agreement between the 2002 American-European-Consensus-Group criteria and the criteria substituted with plasma-anti-M3R for the lip biopsy reached 92% with a significant kappa of 0.824. Anti-M3R enhances sensitivity and specificity for SS diagnosis, correlating with ocular dryness and glandular hypofunction, and the hematological/biological domains of the ESSDAI. Our findings also underscore anti-M3R in SS diagnosis, where clinical assessments by multi-disciplinary specialists, such as lip biopsy, sialometry, or ocular evaluation, are limited.
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影响因子：
3.7
作者：
Lee BH;Gauna AE;Perez G;Park YJ;Pauley KM;Kawai T;Cha S
通讯作者：
Cha S
DOI：
10.1016/j.jcjo.2015.05.007
发表时间：
2015-08-01
影响因子：
4.2
作者：
Eom, Youngsub;Lee, Jong-Suk;Song, Jong Suk
通讯作者：
Song, Jong Suk
影响因子：
--
作者：
Gao, JH;Cha, SH;Peck, AB
通讯作者：
Peck, AB
影响因子：
7.9
作者：
Exum NG;Pisanic N;Granger DA;Schwab KJ;Detrick B;Kosek M;Egorov AI;Griffin SM;Heaney CD
通讯作者：
Heaney CD
影响因子：
--
作者：
DANIELS, TE;WHITCHER, JP
通讯作者：
WHITCHER, JP