Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.
Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.
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DOI：
10.1371/journal.pbio.3001509
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发表时间：
2022-01
期刊：
影响因子：
9.8
通讯作者：
Zelano C
中科院分区：
文献类型：
--
作者：
Yang Q;Zhou G;Noto T;Templer JW;Schuele SU;Rosenow JM;Lane G;Zelano C
对神经元振荡的研究为视觉、听觉和体感知觉的机制提供了实质性的见解。然而，人类嗅觉系统的这类研究进展滞后。因此，人们对人类嗅觉系统的电生理特性知之甚少，尤其是刺激驱动的高频振荡是否在气味处理中发挥作用尚不清楚。在这里，我们使用了在气味识别任务中来自人类梨状皮质的直接颅内记录，以表明三个关键的振荡节律是人类嗅觉皮质对气味反应的组成部分：气味诱导人类梨状皮质的theta、beta和Gamma节律。我们进一步表明，这些节奏与知觉行为有明显的关系。气味引发的伽马振荡只有在气味被准确感知的试验中才会发生，伽马振荡的特征预测气味识别的准确性，这表明它们对人类的气味识别感知至关重要。我们还发现，只有当气味存在时，高频振荡的幅度才由嗅觉开始后不久的低频信号的相位组织起来。我们的发现加强了之前关于theta振荡的工作，表明人类梨状皮质中的伽马振荡对于气味识别是重要的，并构成了对人脑对气味的特征电生理反应的强有力的识别。未来的工作将确定我们识别的不同的振荡是否反映了气味刺激的不同感知特征。来自人类嗅觉皮质的颅内记录显示了对气味的特有的光谱-时间反应，包括theta，beta和Gamma振荡，并表明高频反应对于准确感知气味至关重要。
Studies of neuronal oscillations have contributed substantial insight into the mechanisms of visual, auditory, and somatosensory perception. However, progress in such research in the human olfactory system has lagged behind. As a result, the electrophysiological properties of the human olfactory system are poorly understood, and, in particular, whether stimulus-driven high-frequency oscillations play a role in odor processing is unknown. Here, we used direct intracranial recordings from human piriform cortex during an odor identification task to show that 3 key oscillatory rhythms are an integral part of the human olfactory cortical response to smell: Odor induces theta, beta, and gamma rhythms in human piriform cortex. We further show that these rhythms have distinct relationships with perceptual behavior. Odor-elicited gamma oscillations occur only during trials in which the odor is accurately perceived, and features of gamma oscillations predict odor identification accuracy, suggesting that they are critical for odor identity perception in humans. We also found that the amplitude of high-frequency oscillations is organized by the phase of low-frequency signals shortly following sniff onset, only when odor is present. Our findings reinforce previous work on theta oscillations, suggest that gamma oscillations in human piriform cortex are important for perception of odor identity, and constitute a robust identification of the characteristic electrophysiological response to smell in the human brain. Future work will determine whether the distinct oscillations we identified reflect distinct perceptual features of odor stimuli. Intracranial recordings from human olfactory cortex reveal a characteristic spectrotemporal response to odors, including theta, beta and gamma oscillations, and show that high-frequency responses are critical for accurate perception of odors.
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影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
DOI：
10.1016/j.cub.2018.05.011
发表时间：
2018-07-23
期刊：
Current biology : CB
影响因子：
--
作者：
Carlson KS;Gadziola MA;Dauster ES;Wesson DW
通讯作者：
Wesson DW
影响因子：
2.5
作者：
Barrie, JM;Freeman, WJ;Lenhart, MD
通讯作者：
Lenhart, MD
影响因子：
3.4
作者：
Buonviso, N;Amat, C;Sicard, G
通讯作者：
Sicard, G