A model for intervention research in late-life depression.
A model for intervention research in late-life depression.
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DOI：
10.1002/gps.2287
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发表时间：
2009-12
影响因子：
4
通讯作者：
Bruce, Martha L.
中科院分区：
文献类型：
--
作者：
Alexopoulos, George S.;Bruce, Martha L.
作为旨在减轻晚年抑郁症负担的新干预措施的作用的概念图。我们确定了干预研究需要解决的三个问题：1)鉴于现有的治疗方法使许多老年人抑郁和残疾，需要新的干预措施；2)需要程序使社区机构能够提供已知有效的干预措施；以及3)需要增加抑郁症老年人获得护理的机会。我们的模型根据他们在服务抑郁症老年人方面的作用以及他们在有效性、有效性、实施、传播测试连续体中的地位来对新的干预措施进行排序。我们描述了我们研究所设计的三种干预措施，以例证在模型的不同水平上的干预研究。一个共同的要素是，每一次干预都在服务的个人一级和提供护理的社区机构一级使护理个性化。为此，每一种干预措施都旨在适应患者和机构的优势和局限性，并引入患者环境和社区机构所需的变化，以吸收新的干预措施。我们认为，该模型为如何缩短测试周期并为社区带来迫切需要的新治疗和实施方法提供了概念性指导。虽然复制研究很重要，但建议大多数支持应该指向那些承担合理风险的项目，并在充分的初步证据之后，沿着测试连续体进行下一步。
To serve as a conceptual map of the role of new interventions designed to reduce the burden of late life depression. We identified three needs to be addressed by intervention research: 1) The need for novel interventions given that the existing treatments leave many older adults depressed and disabled; 2) the need for procedures enabling community-based agencies to offer interventions of known efficacy with fidelity; and 3) the need to increase access of depressed older adults to care. Our model orders novel interventions according to their role in serving depressed older adults and according to their position in the efficacy, effectiveness, implementation, dissemination testing continuum. We describe three interventions designed by our Institute to exemplify intervention research at different level of the model. A common element is that each intervention personalizes care both at the level of the individuals served and the level of community agencies providing care. To this end, each intervention is designed to accommodate the strengths and limitations of both patients and agencies and introduces changes in the patients’ environment and community agencies needed in order to assimilate the new intervention. We suggest that this model provides conceptual guidance on how to shorten the testing cycle and bring urgently needed novel treatments and implementation approaches to the community. While replication studies are important, propose that most of support should be directed to those projects that take rational risks, and after adequate preliminary evidence, make the next step along the testing continuum.
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影响因子：
7.2
作者：
Alexopoulos, GS
通讯作者：
Alexopoulos, GS
影响因子：
4
作者：
Aizenstein, HJ;Nebes, RD;DeKosky, ST
通讯作者：
DeKosky, ST
影响因子：
3.7
作者：
Egner, Tobias;Etkin, Amit;Hirsch, Joy
通讯作者：
Hirsch, Joy
影响因子：
2.6
作者：
Elderkin-Thompson, V;Kumar, A;Gur, RE
通讯作者：
Gur, RE
影响因子：
8.3
作者：
Hackett, ML;Anderson, CS;House, AO
通讯作者：
House, AO