Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
复制标题
叶酸补充剂可抑制睡眠不足引起的端粒功能障碍和衰老相关分泌表型 (SASP)
DOI：
10.1155/2019/4569614
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发表时间：
2019-12
影响因子：
--
通讯作者：
Feng Wang
中科院分区：
文献类型：
--
作者：
Xiaoning Zhang;Yuwen Wang;Rui Zhao;Xianyun H;Yang Liu;Lei Sui;Feng Wang
据报道，睡眠剥夺会引起氧化应激，并被假设诱发随后的衰老相关疾病，包括慢性炎症、阿尔茨海默病和心血管疾病。然而，睡眠剥夺如何导致睡眠缺乏症的发病机制仍不完全清楚。因此，需要更有效的治疗睡眠缺乏症的方法。因此，为了更好地了解睡眠不足障碍的详细机制，本研究采用多平台方法建立了睡眠剥夺小鼠模型。在睡眠剥夺小鼠中观察到自由基的积累和衰老相关分泌表型（SASP）。此外，我们基于小鼠和人类群体的研究都表明，端粒缩短和端粒特异性DNA损伤的形成在失眠的个体中显着增加。令我们惊讶的是，叶酸的补充大大改善了小鼠衰老相关细胞因子的分泌和端粒损伤。血清基线叶酸水平高的个体对端粒缩短的抵抗力增加，这是由失眠引起的。因此，我们得出结论，叶酸补充剂可以有效地抵消睡眠剥夺引起的端粒功能障碍和相关的衰老表型，这可能会改善失眠患者的预后。
Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer's disease, and cardiovascular disease. However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined. Accordingly, more effective treatment methods for sleep deficiency disorder are needed. Thus, to better understand the detailed mechanism of sleep deficiency disorder, a sleep deprivation mouse model was established by the multiple platform method in our study. The accumulation of free radicals and senescence-associated secretory phenotype (SASP) was observed in the sleep-deprived mice. Moreover, our mouse and human population-based study both demonstrated that telomere shortening and the formation of telomere-specific DNA damage are dramatically increased in individuals suffering from sleeplessness. To our surprise, the secretion of senescence-associated cytokines and telomere damage are greatly improved by folic acid supplementation in mice. Individuals with high serum baseline folic acid levels have increased resistance to telomere shortening, which is induced by insomnia. Thus, we conclude that folic acid supplementation could be used to effectively counteract sleep deprivation-induced telomere dysfunction and the associated aging phenotype, which may potentially improve the prognosis of sleeplessness disorder patients.
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影响因子：
9.1
作者：
Mullington, Janet M.;Haack, Monika;Toth, Maria;Serrador, Jorge A.;Meier-Ewert, Hans K.
通讯作者：
Meier-Ewert, Hans K.
长期持久性有机污染物暴露引起端粒功能障碍和衰老相关的秘书表型
DOI：
10.1093/gerona/gly002
发表时间：
2018-07-09
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Yuan J;Liu Y;Wang J;Zhao Y;Li K;Jing Y;Zhang X;Liu Q;Geng X;Li G;Wang F
通讯作者：
Wang F
影响因子：
5.6
作者：
Saha SK;Lee SB;Won J;Choi HY;Kim K;Yang GM;Dayem AA;Cho SG
通讯作者：
Cho SG
影响因子：
4.4
作者：
Qin, Bing;Deng, Yunlong
通讯作者：
Deng, Yunlong
具有客观短睡眠持续时间的失眠：生物学上最严重的表型。
影响因子：
10.5
作者：
Vgontzas, Alexandros N.;Fernandez-Mendoza, Julio;Liao, Duanping;Bixler, Edward.
通讯作者：
Bixler, Edward.