Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder.
Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder.
复制标题
具有客观短睡眠持续时间的失眠：生物学上最严重的表型。
DOI：
10.1016/j.smrv.2012.09.005
复制
发表时间：
2013-08
影响因子：
10.5
通讯作者：
Bixler, Edward.
中科院分区：
文献类型：
--
作者：
Vgontzas, Alexandros N.;Fernandez-Mendoza, Julio;Liao, Duanping;Bixler, Edward.
关键词：
直到最近，还没有建立慢性失眠与明显的医疗发病率的关联，其诊断仅基于主观投诉。认知情感和皮质唤醒，应力系统的两个肢体激活以及高血压的风险更高，心率变异性，糖尿病，糖尿病，神经认知障碍和死亡率。激活压力系统或医疗并发症的肢体的迹象，第一个表型与不懈的过程有关我们更有可能使失眠的睡眠持续时间短，这是在患者家庭环境中获得的生物严重程度和医疗影响的可靠标志。在临床办公室环境中客观的正常睡眠持续时间具有主要的心理根源，并且可能仅对心理干预措施做出更好的反应。
Until recently, the association of chronic insomnia with significant medical morbidity was not established and its diagnosis was based solely on subjective complaints. We present evidence that insomnia with objective short sleep duration is the most biologically severe phenotype of the disorder, as it is associated with cognitive-emotional and cortical arousal, activation of both limbs of the stress system, and a higher risk for hypertension, impaired heart rate variability, diabetes, neurocognitive impairment, and mortality. Also, it appears that objective short sleep duration is a biological marker of genetic predisposition to chronic insomnia. In contrast, insomnia with objective normal sleep duration is associated with cognitive-emotional and cortical arousal and sleep misperception but not with signs of activation of both limbs of the stress system or medical complications. Furthermore, the first phenotype is associated with unremitting course, whereas the latter is more likely to remit. We propose that short sleep duration in insomnia is a reliable marker of the biological severity and medical impact of the disorder. Objective measures of sleep obtained in the home environment of the patient would become part of the routine assessment of insomnia patients in a clinician’s office setting. We speculate that insomnia with objective short sleep duration has primarily biological roots and may respond better to biological treatments, whereas insomnia with objective normal sleep duration has primarily psychological roots and may respond better to psychological interventions alone.
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DOI：
10.1523/jneurosci.1809-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cano G;Mochizuki T;Saper CB
通讯作者：
Saper CB
影响因子：
4.7
作者：
Bastien, CH;Fortier-Brochu, É;Morin, CM
通讯作者：
Morin, CM
影响因子：
5.6
作者：
BONNET, MH;ARAND, DL
通讯作者：
ARAND, DL
影响因子：
3.3
作者：
Bonnet, MH;Arand, DL
通讯作者：
Arand, DL
影响因子：
10.6
作者：
Backhaus, Jutta;Junghanns, Klaus;Hohagen, Fritz
通讯作者：
Hohagen, Fritz