Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets.
Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets.
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DOI：
10.2217/fmb.13.162
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发表时间：
2014
影响因子：
3.1
通讯作者：
Isberg R
中科院分区：
文献类型：
--
作者：
Isaac DT;Isberg R
巨噬细胞是抵抗入侵微生物的免疫防御的前线。然而，微生物已经进化出多种不同的机制来阻碍这些宿主的免疫防御并在细胞内繁衍生息。嗜肺军团菌是一种变形虫和哺乳动物吞噬细胞的革兰氏阴性病原体，就是这样一种微生物。在人类中，它会导致一种可能致命的肺炎，称为军团病。军团菌配备了毒力所需的 Icm/Dot IV 型分泌系统和大约 300 个易位蛋白，能够进入宿主细胞，指导其自身液泡室的生物发生，并建立复制生态位，在裂解宿主细胞之前在其中生长到高水平。了解这种细菌发病机制的努力集中在表征其许多效应子的分子活性。在本文中，我们重点介绍了最近在了解军团菌效应器如何介导宿主与病原体相互作用方面取得的进展。
Macrophages are the front line of immune defense against invading microbes. Microbes, however, have evolved numerous and diverse mechanisms to thwart these host immune defenses and thrive intracellularly. Legionella pneumophila, a Gram-negative pathogen of amoebal and mammalian phagocytes, is one such microbe. In humans, it causes a potentially fatal pneumonia referred to as Legionnaires' disease. Armed with the Icm/Dot type IV secretion system, which is required for virulence, and approximately 300 translocated proteins, Legionella is able to enter host cells, direct the biogenesis of its own vacuolar compartment, and establish a replicative niche, where it grows to high levels before lysing the host cell. Efforts to understand the pathogenesis of this bacterium have focused on characterizing the molecular activities of its many effectors. In this article, we highlight recent strides that have been made in understanding how Legionella effectors mediate host-pathogen interactions.
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DOI：
10.1126/science.1227026
发表时间：
2012-11-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Choy A;Dancourt J;Mugo B;O'Connor TJ;Isberg RR;Melia TJ;Roy CR
通讯作者：
Roy CR
影响因子：
3.4
作者：
Heidtman M;Chen EJ;Moy MY;Isberg RR
通讯作者：
Isberg RR
影响因子：
30.3
作者：
Arasaki K;Toomre DK;Roy CR
通讯作者：
Roy CR
影响因子：
3.4
作者：
Amer, AO;Swanson, MS
通讯作者：
Swanson, MS
影响因子：
3.1
作者：
Derré, I;Isberg, RR
通讯作者：
Isberg, RR