Dynamics of perinatal bovine leukemia virus infection.
Dynamics of perinatal bovine leukemia virus infection.
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DOI：
10.1186/1746-6148-10-82
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发表时间：
2014-04-04
影响因子：
2.6
通讯作者：
Trono K
中科院分区：
文献类型：
--
作者：
Gutiérrez G;Alvarez I;Merlini R;Rondelli F;Trono K
牛白血病病毒(BLV)在包括阿根廷在内的许多国家高度流行。由于防止受感染动物的传播对于打破BLV传播循环至关重要，因此了解幼年动物BLV感染的病理生理学很重要，因为它们是动物运动的主要来源。在这项工作中，我们测定了感染的新生牛犊从出生到第一次分娩(36个月)的前病毒载量和抗体效价。所有研究中的牛犊都出生在感染母牛的母牛身上，母牛血液中的前病毒载量(PVL)高，初乳中的抗体效价高，可检测到前病毒。7头小牛中有5头出生时PVL较低。所有动物都达到了超过1%感染的外周血单核细胞(PBMC)的PVL，3只在3个月，1只在6个月，1只在12个月。高PVL持续到研究结束，在两个动物中，每个细胞超过一个BLV拷贝。另外两头小牛从出生到研究结束都保持着较高的PVL。在第一个样本中，7头小牛中有6头的抗体效价达到32或更高。这些在3-6个月至16个月或更低时腐烂，然后在这一点之后再次增加。在出生第一周感染的小牛可能在BLV向敏感动物的早期传播中发挥积极作用，因为它们的PVL在前12个月上升，并持续数年。及早消除病毒可能有助于防止将病毒传染给易受感染的幼年动物及其后代。据我们所知，这是首次研究BLV前病毒载量和抗体滴度在新生感染牛犊中的动态变化。
Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the main source of animal movement. In this work, we determined the proviral load and antibody titers of infected newborn calves from birth to first parturition (36 months). All calves under study were born to infected dams with high proviral load (PVL) in blood and high antibody titers and detectable provirus in the colostrum. The PVL for five out of seven calves was low at birth. All animals reached PVLs of more than 1% infected peripheral blood mononuclear cells (PBMCs), three at 3 months, one at 6 months, and one at 12 months. High PVLs persisted until the end of the study, and, in two animals, exceeded one BLV copy per cell. Two other calves maintained a high PVL from birth until the end of the study. Antibody titers were 32 or higher in the first sample from six out of seven calves. These decayed at 3–6 months to 16 or lower, and then increased again after this point. Calves infected during the first week of life could play an active role in early propagation of BLV to susceptible animals, since their PVL raised up during the first 12 months and persist as high for years. Early elimination could help to prevent transmission to young susceptible animals and to their own offspring. To our knowledge, this is the first study of the kinetics of BLV proviral load and antibody titers in newborn infected calves.
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影响因子：
3.3
作者：
Trono, KG;Mariano, D;Carrillo, C
通讯作者：
Carrillo, C
影响因子：
5.4
作者：
Pyeon, D;OReilly, KL;Splitter, GA
通讯作者：
Splitter, GA
影响因子：
3.3
作者：
Pomier C;Alcaraz MT;Debacq C;Lançon A;Kerkhofs P;Willems L;Wattel E;Mortreux F
通讯作者：
Mortreux F
影响因子：
4.6
作者：
Umeki, Kazumi;Hisada, Michie;Okayama, Akihiko
通讯作者：
Okayama, Akihiko
影响因子：
2.6
作者：
Gutierrez, Geronimo;Carignano, Hugo;Trono, Karina
通讯作者：
Trono, Karina